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Details for Product No. ABIN1003347

RAR-Related Orphan Receptor C (RORC) antibody

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Antigen
Synonyms NR1F3, RORG, RZR-GAMMA, RZRG, TOR
Reactivity
»Alternatives Human, Mouse (Murine)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunocytochemistry (ICC)
Pubmed 4 references available
Catalog no. ABIN1003347
Quantity 100 µg
Price
514.01 $   Plus shipping costs $45.00
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Availability Will be delivered in 6 to 7 Business Days
Immunogen Rabbit polyclol TOR antibody was raised against a 15 amino acid peptide from near the amino terminus of human TOR (Genbank accession No. NP_004949).
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name TOR (Target of Rapamycin)
Background The mammalian Target of Rapamycin (TOR, also known as mTOR) is an evolutionarily conserved serine/threonine kinase that regulates cell growth and cell cycle through its ability to integrate signals from nutrient levels and growth factors. It was initially discovered as a kinase whose ability to stimulate T cell proliferation in response to IL-2 could be inhibited by the immunosuppressive drug rapamycin. Rapamycin inhibits TOR in other cell types resulting in reduced cell growth and reduced rates of cell cycle and cell proliferation. TOR is normally associated with the regulatory proteins RAPTOR and GbetaL. Its downstream targets are thought to be the ribosomal protein S6 kinases and the eukaryotic initiation factor 4E binding proteins (4EBPs). Regulation of these protein families allows TOR to control protein biosynthesis.
Application Notes TOR antibody can be used for the detection of TOR by Western blot at 1 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunocytochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Sabatini, Erdjument-Bromage, Lui et al.: "RAFT1: a mammalian protein that binds to FKBP12 in a rapamycin-dependent fashion and is homologous to yeast TORs." in: Cell, Vol. 78, Issue 1, pp. 35-43, 1994 (PubMed).

Cardenas, Zhu, Heitman: "Molecular mechanisms of immunosuppression by cyclosporine, FK506, and rapamycin." in: Current opinion in nephrology and hypertension, Vol. 4, Issue 6, pp. 472-7, 1996 (PubMed).

Shamji, Nghiem, Schreiber: "Integration of growth factor and nutrient signaling: implications for cancer biology." in: Molecular cell, Vol. 12, Issue 2, pp. 271-80, 2003 (PubMed).

Fingar, Blenis: "Target of rapamycin (TOR): an integrator of nutrient and growth factor signals and coordinator of cell growth and cell cycle progression." in: Oncogene, Vol. 23, Issue 18, pp. 3151-71, 2004 (PubMed).

Alternatives for antigen "RAR-Related Orphan Receptor C (RORC)", type "Antibodies"
Hosts (83), (22), (6), (2)
Reactivities (104), (60), (32), (31), (29), (25), (13), (7), (1), (1), (1), (1)
Applications (71), (29), (24), (20), (13), (5), (3), (2), (1)
Conjugates (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (21), (11), (11), (4), (4), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1)
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