Fas Apoptotic Inhibitory Molecule 3 (FAIM3) antibody

Details for Product No. ABIN1003348
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Antigen
Synonyms FAIM3, FCMR, TOSO, 1810037B05Rik, FcmuR, Toso
Reactivity
Human
(36), (12), (12)
Host
Rabbit
(30), (6)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB)
(27), (9), (8), (7), (5), (1), (1), (1), (1), (1)
Pubmed 2 references available
Quantity 100 μg
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Catalog No. ABIN1003348
514.01 $
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Immunogen Toso antibody was raised against a 13 amino acid peptide from near the carboxy terminus of human Toso.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name Toso (Fas Apoptotic Inhibitory Molecule 3)
Background Apoptosis is an important process by which normal tissue homeostasis and function are maintained. One of the major signals that regulate this process is mediated by the activation of the Fas receptor by its ligand. This leads to the formation of a Fas-associated death domain (FADD)- containing death-inducing signaling complex and the activation of caspase-8, which in turn activates downstream effector caspases, such as caspase-3 and -7. Recent experiments have shown that overexpression of Toso, a novel regulator of Fas-induced apoptosis in lymphoid cells, in Jurkat cells as well as transgenic mice render these cells resistant to Fas-induced apoptosis but not to TRAIL-induced apoptosis. Furthermore, Toso was found to associate with FADD, suggesting that Toso functions by disrupting the formation of the death-inducing signaling complex. Despite its predicted molecular weight, Toso often migrates at 60 kDa in SDS-PAGE.
Application Notes Toso antibody can be used for detection of Toso by Western blot at 1 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Hitoshi, Lorens, Kitada et al.: "Toso, a cell surface, specific regulator of Fas-induced apoptosis in T cells." in: Immunity, Vol. 8, Issue 4, pp. 461-71, 1998 (PubMed).

Curtin, Cotter: "Live and let die: regulatory mechanisms in Fas-mediated apoptosis." in: Cellular signalling, Vol. 15, Issue 11, pp. 983-92, 2003 (PubMed).

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