TRAF Family Member-Associated NFKB Activator (TANK) (C-Term) antibody

Details for Product No. ABIN1003352
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Antigen
Synonyms C86182, E430026L09Rik, I-TRAF, ITRAF, TRAF2
Epitope
C-Term
(17), (14), (7), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(80), (35), (35), (2), (2), (2)
Host
Rabbit
(75), (3), (3), (1), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(72), (30), (19), (16), (10), (9), (9), (7), (7), (3), (3)
Pubmed 4 references available
Quantity 100 µg
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Catalog No. ABIN1003352
514.01 $
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Immunogen TANK antibody was raised against a 14 amino acid peptide from near the carboxy terminus of human TANK.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name TRAF Family Member Associated NF-kappaB Activator
Background TANK was initially identified as a novel TRAF-interacting protein that regulated TRAF-mediated signal transduction. Specifically, ligand binding by surface receptors in the tumor necrosis factor (TNF) receptor and Toll/Interleukin-1 (IL-1) receptor families lead to the formation of a TRAF/TANK complex that mediates the activation of the transcription factor NF-kappaB. This activation of NF-kappaB occurs through an association with the kinases IKKepsilon and TBK1. More recently, it was shown that these proteins can then form a complex with NEMO, a protein that regulates the activity of the IkappaB complex. This suggests that in addition to the possibility that TBK1 and IKKepsilon activate the IKKs, the association with the IKK complex may help these kinases modulate other functions, such as the transactivation potential of NF-kappaB proteins. At least two isoforms of TANK are known to exist.
Application Notes This antibody can be used for the detection of TANK by Western blot at 1 – 2 myg/ml. Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far. This antibody is human, rat and mouse reactive.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Cheng, Baltimore: "TANK, a co-inducer with TRAF2 of TNF- and CD 40L-mediated NF-kappaB activation." in: Genes & development, Vol. 10, Issue 8, pp. 963-73, 1996 (PubMed).

Rothe, Xiong, Shu et al.: "I-TRAF is a novel TRAF-interacting protein that regulates TRAF-mediated signal transduction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 16, pp. 8241-6, 1996 (PubMed).

Pomerantz, Baltimore: "NF-kappaB activation by a signaling complex containing TRAF2, TANK and TBK1, a novel IKK-related kinase." in: The EMBO journal, Vol. 18, Issue 23, pp. 6694-704, 2000 (PubMed).

Chariot, Leonardi, Muller et al.: "Association of the adaptor TANK with the I kappa B kinase (IKK) regulator NEMO connects IKK complexes with IKK epsilon and TBK1 kinases." in: The Journal of biological chemistry, Vol. 277, Issue 40, pp. 37029-36, 2002 (PubMed).

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