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Details for Product No. ABIN1003468

Mitochondrial Antiviral Signaling Protein (MAVS) (N-Term) antibody

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Antigen
Synonyms CARDIF, IPS-1, IPS1, VISA, D430028G21Rik, Visa, cardif
Epitope
»Alternatives N-Term
Reactivity
»Alternatives Human, Mouse (Murine), Rat (Rattus)
Host
»Alternatives Rabbit
Clonality Polyclonal
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
Pubmed 2 references available
Catalog no. ABIN1003468
Quantity 100 µg
Price
514.01 $   Plus shipping costs $45.00
Shipping to
Availability Will be delivered in 6 to 7 Business Days
Immunogen VISA antibody was raised in rabbits against a 13 amino acid peptide from near the amino terminus of human VISA.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name VISA
Background Two distinct signaling pathways activate the host innate immunity against viral infection. One pathway is reliant on members of the Toll-like receptor (TLR) family while the other uses the RNA helicase RIG-I as a receptor for intracellular viral double-stranded RNA as a trigger for the immune response. VISA is a mitochondrial membrane protein that was identified as a critical component in the IFN-b signaling pathways that recruits IRF-3 to RIG-I, leading to its activation and that of NF-kappaB. VISA is also thought to interact with other components of the innate immune pathway such as the TLR adapter protein TRIF, TRAF2 and TRAF6. VISA also interacts with the IKKalpha, IKKbeta and IKKepsilon kinases through its C-terminal region. Cleavage of this region by the Hepatitis C virus (HCV) protease allows HCV to escape the host immune system. At least three isoforms of VISA are known to exist.
Application Notes VISA antibody can be used for detection of VISA by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user). Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Xu, Wang, Han et al.: "VISA is an adapter protein required for virus-triggered IFN-beta signaling." in: Molecular cell, Vol. 19, Issue 6, pp. 727-40, 2005 (PubMed).

Seth, Sun, Chen: "Antiviral innate immunity pathways." in: Cell research, Vol. 16, Issue 2, pp. 141-7, 2006 (PubMed).

Alternatives for antigen "Mitochondrial Antiviral Signaling Protein (MAVS)", type "Antibodies"
Hosts (56), (2)
Reactivities (53), (35), (32), (13), (1), (1), (1)
Applications (49), (20), (19), (12), (10), (4), (2), (2), (2), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (13), (6), (5), (3), (2), (2), (1), (1), (1)
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