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West Nile Virus Envelope Protein (C-Term) antibody

Details for Product No. ABIN1003479
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Antigen
Epitope
C-Term
(3), (2), (2), (1)
Reactivity
West Nile Virus (WNV)
(16)
Host
Rabbit
(11), (5)
Clonality
Polyclonal
Application
ELISA
(11), (5), (5)
Pubmed 4 references available
Quantity 100 µg
Shipping to United States (Change)
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Catalog No. ABIN1003479
514.01 $
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Immunogen Rabbit polyclol WNV Envelope antibody was raised against a synthetic peptide corresponding to 14 amino acids at the C-terminus of the WNV Envelope protein (Genbank accession no. NP_776014).
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Background West Nile Virus (WNV) is a member of the Flaviviridae, a plus-stranded virus family that includes St. Louis encephalitis virus, yellow fever virus, and Dengue virus. WNV was initially isolated in 1937 in the West Nile region of Uganda and has become prevalent in Africa, Asia, and Europe. It has rapidly spread across the United States with cases being observed in every continental state. Virus particles consist of a dense core made up of the core/capsid protein encapsulating the RNA genome surrounded by a membrane envelope embedded with envelope and matrix proteins. While the viral core protein is thought to contribute to the WNV-associated inflammation via apoptosis induced though the caspase-9 pathway, the highly glycosylated envelope protein plays a major role for WNV entry into target cells as this entry can be inhibited by using a recombinant domain III from the envelope glycoprotein. The WNV receptor has recently been identified as alpha v beta 3 integrin
Application Notes West Nile virus envelope protein antibody can be used for the detection of the West Nile virus envelope protein in ELISA. It will detect 10 ng of free peptide at 1 µg/ml. (Optimal dilution should be determined by user.) Other applications are pending.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Yang, Ramanathan, Muthumani et al.: "Induction of inflammation by West Nile virus capsid through the caspase-9 apoptotic pathway." in: Emerging infectious diseases, Vol. 8, Issue 12, pp. 1379-84, 2002 (PubMed).

Gould, Fikrig: "West Nile virus: a growing concern?" in: The Journal of clinical investigation, Vol. 113, Issue 8, pp. 1102-7, 2004 (PubMed).

Chu, Ng: "Interaction of West Nile virus with alpha v beta 3 integrin mediates virus entry into cells." in: The Journal of biological chemistry, Vol. 279, Issue 52, pp. 54533-41, 2004 (PubMed).

Chu, Rajamanonmani, Li et al.: "Inhibition of West Nile virus entry by using a recombinant domain III from the envelope glycoprotein." in: The Journal of general virology, Vol. 86, Issue Pt 2, pp. 405-12, 2005 (PubMed).

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