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Ectodysplasin A2 Receptor antibody (EDA2R)

Details for Product anti-EDA2R Antibody No. ABIN1003491, Supplier: Log in to see
Antigen
  • 9430060M22Rik
  • EDA-A2R
  • EDAA2R
  • RGD1564025
  • TNFRSF27
  • XEDAR
  • Xedar
Reactivity
Human
89
15
15
Host
Rabbit
71
18
Clonality
Polyclonal
Conjugate
This Ectodysplasin A2 Receptor antibody is un-conjugated
5
5
5
4
4
4
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
73
34
11
11
9
3
1
1
Supplier
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Immunogen XEDAR antibody was raised against recombint human XEDAR.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name X-linked Ectodysplasin-A2 Receptor (EDA2R Antibody Abstract)
Background X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-kappaB and JNK pathways. Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis. The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment.
Application Notes XEDAR antibody can be used for the detection of XEDAR by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4 °C, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Background publications Sinha, Chaudhary: "Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism." in: The Journal of biological chemistry, Vol. 279, Issue 40, pp. 41873-81, 2004

Sinha, Zachariah, Quiñones, Shindo, Chaudhary: "Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor." in: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 44953-61, 2002

Yan, Wang, Hymowitz, Schilbach, Lee, Goddard, de Vos, Gao, Dixit: "Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors." in: Science (New York, N.Y.), Vol. 290, Issue 5491, pp. 523-7, 2000