Ectodysplasin A2 Receptor (EDA2R) antibody

Details for Product No. ABIN1003491
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Antigen
Synonyms EDA-A2R, EDAA2R, TNFRSF27, XEDAR, 9430060M22Rik, Xedar, RGD1564025
Reactivity
Human
(62), (13), (11)
Host
Rabbit
(47), (15)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(46), (28), (9), (9), (6), (3), (3), (1)
Pubmed 3 references available
Quantity 100 μg
Shipping to United States (Change)
Availability Will be delivered in 6 to 7 Business Days
Request Want additional data for this product?

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Catalog No. ABIN1003491
514.01 $
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  • +1 404 474 4654
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Immunogen XEDAR antibody was raised against recombint human XEDAR.
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name X-linked Ectodysplasin-A2 Receptor
Background X-linked ectodysplasin-A2 receptor (XEDAR) is a recently isolated member of the tumor necrosis factor receptor family that is highly expressed during embryonic development and binds to ectodysplatin-A2 (EDA-A2). Two predominantly expressed isoforms, XEDAR-s and XEDAR-L, differ by only a 21-amino region at the juxtamembrane region of the cytoplasmic domain. Neither isoform possesses a death domain and both have been shown to act mainly through TRAF3 and TRAF6 to activate the NF-kappaB and JNK pathways. Cells transfected with XEDAR and treated with EDA-A2 cause the assembly of a secondary complex containing FADD, caspase-8 and caspase-10, leading to the activation caspase-8 and caspase-3, and finally apoptosis. The EDA-A2-induced apoptosis is dependent on caspase-9 activation, as various pharmacological and genetic inhibitors of caspase-8 blocked apoptosis following EDA-A2 treatment.
Application Notes XEDAR antibody can be used for the detection of XEDAR by Western blot at 0.5 – 1 µg/ml. (Optimal dilution should be determined by user.) Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Yan, Wang, Hymowitz et al.: "Two-amino acid molecular switch in an epithelial morphogen that regulates binding to two distinct receptors." in: Science (New York, N.Y.), Vol. 290, Issue 5491, pp. 523-7, 2000 (PubMed).

Sinha, Zachariah, Quiñones et al.: "Role of TRAF3 and -6 in the activation of the NF-kappa B and JNK pathways by X-linked ectodermal dysplasia receptor." in: The Journal of biological chemistry, Vol. 277, Issue 47, pp. 44953-61, 2002 (PubMed).

Sinha, Chaudhary: "Induction of apoptosis by X-linked ectodermal dysplasia receptor via a caspase 8-dependent mechanism." in: The Journal of biological chemistry, Vol. 279, Issue 40, pp. 41873-81, 2004 (PubMed).

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