X-Linked Inhibitor of Apoptosis (XIAP) (C-Term) antibody

Details for Product No. ABIN1003492
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Antigen
Synonyms BIRC4, api3, birc4, ilp1, miha, xlp2, xxiap, API3, IAP-3, ILP1, MIHA, XLP2, hIAP-3, hIAP3, 1110015C02Rik, Aipa, Api3, Birc4, IAP3, ILP-1, mXIAP, riap3
Epitope
C-Term
(17), (14), (6), (4), (4), (4), (4), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine)
(112), (52), (37), (6), (1)
Host
Rabbit
(102), (16)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
ELISA, Western Blotting (WB), Immunohistochemistry (IHC)
(98), (47), (33), (31), (12), (10), (8), (8), (6), (4), (2), (1)
Pubmed 4 references available
Quantity 100 μg
Shipping to United States (Change)
Availability Will be delivered in 6 to 7 Business Days
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Catalog No. ABIN1003492
514.01 $
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Immunogen Rabbit polyclol XIAP antibody was raised against a synthetic peptide corresponding to 13 amino acids at the C-terminus of human XIAP (Genbank accession No. NP_001158).
Isotype IgG
Purification Affinity chromatography purified via peptide column.
Alternative Name X-linked Inhibitor of Apoptosis Protein
Background Apoptosis, or programmed cell death, is related to many diseases, such as cancer. Apoptosis is triggered by a variety of stimuli including members in the TNF family and can be prevented by the inhibitor of apoptosis (IAP) proteins. IAP proteins form a conserved gene family that binds to and inhibits cell death proteases. The X-chromosome linked inhibitor of apoptosis (XIAP) contains 3 baculoviral IAP repeat (BIR) motifs that are essential and sufficient for the binding and inhibition of caspases–3, –7, and –9. Upregulation of XIAP expression can protect cells from apoptosis induced by low level radiation, conversely, decreased XIAP expression by antisense targeting resulted in increased cell death following low level radiation. Two negative regulators, termed XAF-1 and Smac, can bind and inhibit XIAP activity.
Application Notes XIAP antibody can be used for the detection of XIAP by Western blot at 0.5 to 2 µg/ml. (Optimal dilution should be determined by user.) Human kidney cell lysate can be used as positive control. Antibody can also be used for immunohistochemistry and ELISA and might be suited for other applications not tested so far. Anti-XIAP is human and mouse reactive.
Restrictions For Research Use only
Format Liquid
Buffer Antibody is supplied in PBS containing 0.02% sodium azide.
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Antibody can be stored at 4ºC, stable for one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures. During shipment, small volumes of antibody will occasionally become entrapped in the seal of the product vial. For products with volumes of 200 myl or less, we recommend gently tapping the vial on a hard surface or briefly centrifuging the vial in a tabletop centrifuge to dislodge any liquid in the container’s cap.
Storage 4 °C
Expiry Date 12 months
Product cited in: Deveraux, Takahashi, Salvesen et al.: "X-linked IAP is a direct inhibitor of cell-death proteases." in: Nature, Vol. 388, Issue 6639, pp. 300-4, 1997 (PubMed).

Deveraux, Leo, Stennicke et al.: "Cleavage of human inhibitor of apoptosis protein XIAP results in fragments with distinct specificities for caspases." in: The EMBO journal, Vol. 18, Issue 19, pp. 5242-51, 1999 (PubMed).

Holcik, Yeh, Korneluk et al.: "Translational upregulation of X-linked inhibitor of apoptosis (XIAP) increases resistance to radiation induced cell death." in: Oncogene, Vol. 19, Issue 36, pp. 4174-7, 2000 (PubMed).

Schimmer: "Inhibitor of apoptosis proteins: translating basic knowledge into clinical practice." in: Cancer research, Vol. 64, Issue 20, pp. 7183-90, 2004 (PubMed).

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