You are viewing an incomplete version of our website. Please click to reload the website as full version.

Cyclin D1 antibody (CCND1) (C-Term)

Details for Product anti-CCND1 Antibody No. ABIN1020428, Supplier: Login to see
Antigen
  • ccnd1b
  • prad1
  • bcl1
  • d11s287e
  • u21b31
  • ccndbp1
  • ccnd1
  • ZHM
  • CCND1
  • BCL1
  • D11S287E
  • PRAD1
  • U21B31
  • AI327039
  • CycD1
  • Cyl-1
  • bcl-1
  • cD1
  • ccnd1a
  • cb161
  • cycd1
  • etID37810.7
  • fb52e01
  • fc45c08
  • fc83a12
  • id:ibd1198
  • wu:fb52e01
  • wu:fc45c08
  • wu:fc83a12
Alternatives
anti-Human Cyclin D1 antibody for Western Blotting
Epitope
C-Term
78
27
20
13
13
10
10
9
9
8
8
6
6
5
5
4
4
4
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine), Rat (Rattus)
372
133
120
16
13
13
11
9
8
4
3
2
2
2
1
1
1
1
1
Host
Rabbit
306
119
1
1
Clonality
Polyclonal
Conjugate
This Cyclin D1 antibody is un-conjugated
20
15
5
5
2
2
2
2
2
1
1
1
1
1
1
1
1
Application
Western Blotting (WB)
331
159
95
77
74
63
41
36
33
13
8
7
6
3
3
2
2
2
1
1
1
Supplier
Login to see
Supplier Product No.
Login to see
Request

Showcase your results, aid the scientific community, and receive a full refund.

Contribute a validation

Learn more

Available images

Immunogen A synthetic peptide (conjugated with KLH) corresponding to the C-terminal of cyclin D1.
Isotype Ig
Purification affinity purified
Alternative Name Cyclin D1 (CCND1 Antibody Abstract)
Background Background: G1/S-specific cyclin-D1 is a protein that in humans is encoded by the CCND1 gene. Cyclin D1 belongs to the core cell cycle machinery, and it is frequently overexpressed in human cancers. 1 Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle. CCND1 associates with and regulates transcription factors, coactivators, and corepressors that govern histone acetylation and chromatin remodeling proteins. CCND1 also has roles in cellular growth, metabolism, and cellular differentiation. Amplification or overexpression of cyclin D1 plays pivotal roles in the development of a subset of human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer.
Pathways PI3K-Akt Signaling, Cell Division Cycle
Application Notes Western Blot (0.05myg/ml) Other applications have not been tested. The optimal dilutions should be determined by end user.
Restrictions For Research Use only
Format Liquid
Buffer In TBS (pH7.4), 40% Glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Aliquot and store at -20°C for long term (at least one year). Avoid repeated freeze and thaw cycles. Store at 4°C for short term (1 week).
Supplier Images
 image for anti-Cyclin D1 antibody (CCND1) (C-Term) (ABIN1020428) anti-Cyclin D1 (CCND1) (C-Term) antibody
Product cited in: Bienvenu, Jirawatnotai, Elias et al.: "Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen." in: Nature, Vol. 463, Issue 7279, pp. 374-8, 2010 (PubMed).

Fu, Wang, Li et al.: "Minireview: Cyclin D1: normal and abnormal functions." in: Endocrinology, Vol. 145, Issue 12, pp. 5439-47, 2004 (PubMed).