Cyclin D1 (CCND1) (C-Term) antibody

Antigen: Cyclin D1 (CCND1)

Synonyms: BCL1, PRAD1, U21B31, D11S287E, cD1, Cyl-1, bcl-1, AI327039, DIP1, GCIP, Maid, SECC-8, SSEC-8, AU022347, cb161, cycd1, fb52e01, fc83a12, id:ibd1198, wu:fb52e01, wu:fc83a12, MGC109078, ccnd1b, MGC52909, MGC132138, ccnd1, MGC53090, bcl1, prad1, u21b31, MGC69515, d11s287e, CCND1, ccndbp1, MGC137744, ZHM, CCNDBP1, MGC133757, DKFZp468E2216, DKFZp469C1216, DKFZp469H0317

Binding Site: C-Term

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human, Mouse (Murine), Rat (Rattus)

Conjugate: Un-conjugated

Application: Western Blotting (WB)

Catalog no.: ABIN1020428

Additional Information

Alternative name: Cyclin D1

Immunogen: A synthetic peptide (conjugated with KLH) corresponding to the C-terminal of cyclin D1.

Format: Liquid

Isotype: Ig

Description: Background: G1/S-specific cyclin-D1 is a protein that in humans is encoded by the CCND1 gene. Cyclin D1 belongs to the core cell cycle machinery, and it is frequently overexpressed in human cancers. 1 Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle. CCND1 associates with and regulates transcription factors, coactivators, and corepressors that govern histone acetylation and chromatin remodeling proteins. CCND1 also has roles in cellular growth, metabolism, and cellular differentiation. Amplification or overexpression of cyclin D1 plays pivotal roles in the development of a subset of human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer.

Synonyms: BCL1, PRAD1, U21B31, D11S287E, cD1, Cyl-1, bcl-1, AI327039, DIP1, GCIP, Maid, SECC-8, SSEC-8, AU022347, cb161, cycd1, fb52e01, fc83a12, id:ibd1198, wu:fb52e01, wu:fc83a12, MGC109078, ccnd1b, MGC52909, MGC132138, ccnd1, MGC53090, bcl1, prad1, u21b31, MGC69515, d11s287e, CCND1, ccndbp1, MGC137744, ZHM, CCNDBP1, MGC133757, DKFZp468E2216, DKFZp469C1216, DKFZp469H0317

Application Details

Application Notes: Western Blot (0.05myg/ml) Other applications have not been tested. The optimal dilutions should be determined by end user.

Purification: affinity purified

Buffer: In TBS (pH7.4), 40% Glycerol

Preservative: 0.5% BSA, 0.05% Sodium Azide

Storage (Long Term): Aliquot and store at -20°C for long term (at least one year). Avoid repeated freeze and thaw cycles.

Storage (Short Term): Store at 4°C for short term (1 week).

Restrictions: For Research Use Only

Images

anti-Cyclin D1 (CCND1) (C-Term) antibody

Publications

Product: Fu, Wang, Li et al.: "Minireview: Cyclin D1: normal and abnormal functions." in: Endocrinology, Vol. 145, Issue 12, pp. 5439-47, 2004 (PubMed).

Bienvenu, Jirawatnotai, Elias et al.: "Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen." in: Nature, Vol. 463, Issue 7279, pp. 374-8, 2010 (PubMed).