Cyclin D1 (CCND1) (C-Term) antibody

Details for Product No. ABIN1020428
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Antigen
Synonyms
ccnd1b, prad1, bcl1, d11s287e, u21b31, ccndbp1, ccnd1, ZHM, CCND1, BCL1, D11S287E, PRAD1, U21B31, AI327039, CycD1, Cyl-1, bcl-1, cD1, ccnd1a, cb161, cycd1, etID37810.7, fb52e01, fc45c08, fc83a12, id:i ... show more
ccnd1b, prad1, bcl1, d11s287e, u21b31, ccndbp1, ccnd1, ZHM, CCND1, BCL1, D11S287E, PRAD1, U21B31, AI327039, CycD1, Cyl-1, bcl-1, cD1, ccnd1a, cb161, cycd1, etID37810.7, fb52e01, fc45c08, fc83a12, id:ibd1198, wu:fb52e01, wu:fc45c08, wu:fc83a12 show less
Epitope
C-Term
(45), (22), (18), (13), (8), (6), (5), (3), (3), (3), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(277), (108), (100), (32), (19), (10), (9), (4), (2), (2), (1), (1), (1), (1), (1)
Host
Rabbit
(234), (76), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(10), (8), (4), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Application
Western Blotting (WB)
(260), (92), (81), (60), (58), (42), (37), (32), (20), (18), (14), (11), (7), (3), (3), (3), (2), (1)
Pubmed 2 references available
Quantity 100 μg
Shipping to United States (Change)
Availability Will be delivered in 9 to 11 Business Days
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Catalog No. ABIN1020428
183.33 $
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Immunogen A synthetic peptide (conjugated with KLH) corresponding to the C-terminal of cyclin D1.
Isotype Ig
Purification affinity purified
Alternative Name Cyclin D1
Background Background: G1/S-specific cyclin-D1 is a protein that in humans is encoded by the CCND1 gene. Cyclin D1 belongs to the core cell cycle machinery, and it is frequently overexpressed in human cancers. 1 Cyclin D1 encodes the regulatory subunit of a holoenzyme that phosphorylates and inactivates the retinoblastoma protein and promotes progression through the G1-S phase of the cell cycle. CCND1 associates with and regulates transcription factors, coactivators, and corepressors that govern histone acetylation and chromatin remodeling proteins. CCND1 also has roles in cellular growth, metabolism, and cellular differentiation. Amplification or overexpression of cyclin D1 plays pivotal roles in the development of a subset of human cancers including parathyroid adenoma, breast cancer, colon cancer, lymphoma, melanoma, and prostate cancer.
Application Notes Western Blot (0.05myg/ml) Other applications have not been tested. The optimal dilutions should be determined by end user.
Restrictions For Research Use only
Format Liquid
Buffer In TBS (pH7.4), 40% Glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Aliquot and store at -20°C for long term (at least one year). Avoid repeated freeze and thaw cycles. Store at 4°C for short term (1 week).
Supplier Images
anti-Cyclin D1 (CCND1) (C-Term) antibody anti-Cyclin D1 (CCND1) (C-Term) antibody
Product cited in: Fu, Wang, Li et al.: "Minireview: Cyclin D1: normal and abnormal functions." in: Endocrinology, Vol. 145, Issue 12, pp. 5439-47, 2004 (PubMed).

Bienvenu, Jirawatnotai, Elias et al.: "Transcriptional role of cyclin D1 in development revealed by a genetic-proteomic screen." in: Nature, Vol. 463, Issue 7279, pp. 374-8, 2010 (PubMed).

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