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SOX2 antibody (SRY (Sex Determining Region Y)-Box 2)

Details for Product anti-SOX2 Antibody No. ABIN1020451, Supplier: Log in to see
Antigen
  • Qscn6
  • Qsox
  • Sox-2
  • rSOx
  • ANOP3
  • MCOPS3
  • RGD1565646
  • SRY-box2
  • Xsox-2
  • anop3
  • mcops3
  • sox-2
  • lcc
  • ysb
  • cb236
  • wu:fb83g04
  • wu:fc14d07
  • zgc:65860
  • zgc:77389
Reactivity
Human, Mouse (Murine)
313
87
44
13
9
7
7
5
5
4
4
3
2
1
1
1
Host
Rabbit
252
62
7
4
Clonality
Polyclonal
Conjugate
This SOX2 antibody is un-conjugated
17
13
12
11
11
11
3
2
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunohistochemistry (IHC), Western Blotting (WB)
210
145
63
59
54
43
40
33
12
7
6
4
4
3
2
2
2
2
2
2
1
Supplier
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Immunogen A synthetic peptide (conjugated with KLH) corresponding to the sequence of SOX2.
Isotype Ig
Purification affinity purified
Alternative Name SRY (sex determining region Y)-box 2, SOX2 (SOX2 Antibody Abstract)
Background Background: SRY (sex determining region Y)-box 2, also known as SOX2, is a transcription factor that is essential to maintain self-renewal of undifferentiated embryonic stem cells. SOX2 gene encodes a 317-amino acid protein, 1 and lies in an intron of the SOX2OT (SOX2 overlapping transcript) gene with single-exon. 2 SOX2 is expressed early in the embryonic stem cells of the blastocyst and later in the neural stem cells. It is a member of the SOX family of proteins that carry a DNA-binding high-mobility group (HMG) domain and additional domains that regulate embryonic development and cell fate determinations. Mutations in SOX2 can cause not only anophthalmia, but also aplasia of the optic nerve, chiasm and optic tract, as well as modest bilateral sensorineural hearing loss, and global developmental delay, underscoring the importance of SOX2 in early human eye and brain development. 3 And the ectopic expression of SOX2 may be related to abnormal differentiation of colorectal cancer cells.
Pathways
Application Notes Western Blot (0.5-1myg/ml) Immunohistochemistry (2.5myg/ml) Immunocytochemistry (10-25myg/ml) Other applications have not been tested. The optimal dilutions should be determined by end user.
Restrictions For Research Use only
Format Liquid
Buffer In TBS (pH7.4), 40% Glycerol
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C/-20 °C
Storage Comment Aliquot and store at -20°C for long term (at least one year). Avoid repeated freeze and thaw cycles. Store at 4°C for short term (1 week).
Supplier Images
 image for anti-SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (ABIN1020451) anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) antibody
 image for anti-SOX2 antibody (SRY (Sex Determining Region Y)-Box 2) (ABIN1020451) anti-SRY (Sex Determining Region Y)-Box 2 (SOX2) antibody (Image 2)
Product cited in: Tani, Akiyama, Fukamachi et al.: "Transcription factor SOX2 up-regulates stomach-specific pepsinogen A gene expression." in: Journal of cancer research and clinical oncology, Vol. 133, Issue 4, pp. 263-9, 2007 (PubMed).

Hagstrom, Pauer, Reid et al.: "SOX2 mutation causes anophthalmia, hearing loss, and brain anomalies." in: American journal of medical genetics. Part A, Vol. 138A, Issue 2, pp. 95-8, 2005 (PubMed).

Fantes, Ragge, Lynch et al.: "Mutations in SOX2 cause anophthalmia." in: Nature genetics, Vol. 33, Issue 4, pp. 461-3, 2003 (PubMed).

Stevanovic, Zuffardi, Collignon et al.: "The cDNA sequence and chromosomal location of the human SOX2 gene." in: Mammalian genome : official journal of the International Mammalian Genome Society, Vol. 5, Issue 10, pp. 640-2, 1995 (PubMed).