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Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) antibody

Details for Product No. ABIN1027727
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Antigen
Synonyms CG12019, CPDR-1, CPDR-2, DROCPDR, Dmel\\CG12019, E(sev)3B, cdc37, Afu4g10010, P50CDC37, p50, p50Cdc37
Reactivity
Human
(79), (38), (35), (12), (12), (12), (1), (1)
Host
Rabbit
(76), (4)
Clonality
Polyclonal
Conjugate
Un-conjugated
(3), (3), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Western Blotting (WB)
(71), (31), (23), (21), (18), (12), (10), (7), (5)
Pubmed 4 references available
Quantity 100 µg
Options
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The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1027727
295.90 $
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Immunogen Native human Cdc37 full length
Specificity Detects approx. 44.5 kDa.
Purification Protein A Purified
Alternative Name CDC37
Background Hsp90 co-chaperone Cdc37 is a protein that is encoded by the CDC37 gene. It has been found to form complexes with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF1, MOK and elF-2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases. CDC37 is necessary for maintaining prostate tumor cell growth and represents a novel target in the exploration for multi-targeted therapies.
Gene ID 11140
NCBI Accession NP_008996.1
UniProt Q16543
Research Area Cell Cycle, CD Antigens, Surface Receptors of Immune Cells, Heat Shock Proteins
Restrictions For Research Use only
Concentration 1.68 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Stepanova, Leng, Parker et al.: "Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4." in: Genes & development, Vol. 10, Issue 12, pp. 1491-502, 1996 (PubMed).

Dai, Kobayashi, Beach: "Physical interaction of mammalian CDC37 with CDK4." in: The Journal of biological chemistry, Vol. 271, Issue 36, pp. 22030-4, 1996 (PubMed).

Kimura, Rutherford, Miyata et al.: "Cdc37 is a molecular chaperone with specific functions in signal transduction." in: Genes & development, Vol. 11, Issue 14, pp. 1775-85, 1997 (PubMed).

Gray, Prince, Cheng et al.: "Targeting the oncogene and kinome chaperone CDC37." in: Nature reviews. Cancer, Vol. 8, Issue 7, pp. 491-5, 2008 (PubMed).

Validation Images
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