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Cell Division Cycle 37 Homolog (S. Cerevisiae) (CDC37) antibody

Details for Product No. ABIN1027727, Supplier: Log in to see
Antigen
  • CG12019
  • CPDR-1
  • CPDR-2
  • DROCPDR
  • Dmel\\CG12019
  • E(sev)3B
  • cdc37
  • Afu4g10010
  • P50CDC37
  • p50
  • p50Cdc37
Reactivity
Human
122
45
43
4
2
2
1
1
Host
Rabbit
119
5
Clonality
Polyclonal
Conjugate
Un-conjugated
5
5
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Western Blotting (WB)
109
48
45
37
21
16
14
11
6
1
1
Supplier
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Immunogen Native human Cdc37, full length
Specificity Detects ~44.5 kDa.
Purification Protein A Purified
Alternative Name CDC37 (CDC37 Antibody Abstract)
Background HSP90 co-chaperone Cdc37 is a protein that is encoded by the CDC37 gene. It has been found to form complexes with HSP90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF1, MOK and elF-2 alpha kinases. It is thought to play a critical role in directing HSP90 to its target kinases (1, 2). CDC37 is necessary for maintaining prostate tumor cell growth and represents a novel target in the exploration for multi-targeted therapies (3, 4).
Cellular Localization: Cytoplasm
Gene ID 11140
NCBI Accession NP_008996
UniProt Q16543
Research Area Cell Cycle, CD Antigens, Surface Receptors of Immune Cells
Application Notes Recommended Dilution: WB (1:2000), ICC/IF (1:200), optimal dilutions for assays should be determined by the user.
Restrictions For Research Use only
Format Liquid
Concentration 1.68 mg/mL
Buffer PBS pH 7.4, 50 % glycerol, 0.09 % sodium azide
Preservative Sodium azide
Precaution of Use This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Background publications Gray, Prince, Cheng et al.: "Targeting the oncogene and kinome chaperone CDC37." in: Nature reviews. Cancer, Vol. 8, Issue 7, pp. 491-5, 2008 (PubMed).

Kimura, Rutherford, Miyata et al.: "Cdc37 is a molecular chaperone with specific functions in signal transduction." in: Genes & development, Vol. 11, Issue 14, pp. 1775-85, 1997 (PubMed).

Dai, Kobayashi, Beach: "Physical interaction of mammalian CDC37 with CDK4." in: The Journal of biological chemistry, Vol. 271, Issue 36, pp. 22030-4, 1996 (PubMed).

Stepanova, Leng, Parker et al.: "Mammalian p50Cdc37 is a protein kinase-targeting subunit of Hsp90 that binds and stabilizes Cdk4." in: Genes & development, Vol. 10, Issue 12, pp. 1491-502, 1996 (PubMed).