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anti-matrix metalloprotease 1 (MMP1) antibody

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Image for anti-matrix metalloprotease 1 (MMP1) antibody
Antigen: Matrix metalloprotease 1 (MMP1)
Clonality: Polyclonal
Application: Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Reactivity: Human
Host: Rabbit
1 reference available 1 reference available
Quantity: 1ml (100ug/ml approximately) (Product variants)
Price: 562,35 $   (Plus shipping costs and VAT, Invoice in EUR)
Order number: ABIN103982
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Additional Information  » anti-matrix metalloprotease 1 (MMP1) antibody

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Antigen Matrix metalloprotease 1 (MMP1)
Immunogen A synthetic peptide from the middle region of the human MMP-1.
Reactivity Human
Clonality Polyclonal
Format Ig-fraction, Purified
Host Rabbit
Specificity This antibody reacts with a 52 kD protein (unglycosylated) and 57 kD (glycosylated) species of pro form of MMP-1 as well as 42 kD (unglycosylated) and 47 kD (glycosylated) active form of MMP-1. Matrix metalloproteinase (MMPs) are a family of closely related zinc-containing proteolytic enzymes, capable of degrading connective tissue components. MMP-1 appears to be associated with facilitating the tumor spread and invasion of esophageal and colorectal cancers and is associated with poor prognosis. Interstitial collagenase (MMP-1), 73 kD gelatinase A/type IV collagenase (MMP-2) and 92 kD gelatinase B/type IV collagenase (MMP-9) dissolve extracellular matrix and may initiate and promote angiogenesis.

Application Details  » anti-matrix metalloprotease 1 (MMP1) antibody

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Application Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
» Click here to view 1 available protocol!
Application Notes Titer/Working Dilution: This antibody may be diluted to a titer of 1:25-1:50 in an ABC method. However, depending on the staining conditions employed, we suggest that final dilution should be determined by the user. Staining Protocol: We suggest an incubation period of 30 minutes at room temperature. However, depending upon the fixation conditions and the staining system employed, optimal incubation conditions should be determined by the user. Formalin fixed paraffin embedded tissue sections require high temperature antigen unmasking with 10 mM citrate buffer, pH 6.0 prior to immunostaining. Positive Control: Placenta. Cellular localization: Cytoplasmic
Concentration 100ug/ml approximately
Buffer Purified immunoglobulin fraction of rabbit antiserum against MMP-1 containing sodium azide as preservative.
Storage Store the antibody at 2-8o c. Do not use it beyond the expiration date stated on the label.
Research Area Extracellular Matrix
Restrictions For Research Use. CE-certified for In Vitro Diagnostics (IVD) Use in the European Union

Publications  » anti-matrix metalloprotease 1 (MMP1) antibody

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Publications Windsor, Birkedal-Hansen, Birkedal-Hansen et al.: "An internal cysteine plays a role in the maintenance of the latency of human fibroblast collagenase." In: Biochemistry , Vol. 30, Issue 3, pp. 641-7, 1991 (PubMed)

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