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Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) antibody

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Synonyms APPL, DIP13alpha, 2900057D21Rik, 7330406P05Rik, AI585782, AW209077, BB022931, C88264, DIP13, RGD1309388
Mouse (Murine), Rat (Rattus), Human
(54), (22), (15), (4), (4), (1), (1), (1), (1), (1)
(39), (16), (2)
(1), (1), (1), (1), (1), (1)
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunoprecipitation (IP), Western Blotting (WB)
(55), (32), (13), (8), (2), (2), (1), (1)
Pubmed 5 references available
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Quantity 50 μL
Shipping to United States ( )
Availability Will be delivered in 5 to 6 Business Days
Immunogen Purified APPL fusion
Clone N-A
Cross-Reactivity Mouse (Murine)
Characteristics Predicted molecular weight: 80 kDa.
Purification Unpurified
Alternative Name APPL1 (APPL1 Antibody Abstract)
Background Synonyms:
Adaptor Protein Containing pH Domain antibody,Adaptor protein containing pH domain PTB domain and leucinezipper motif 1 antibody,Adaptor protein containing pH domain PTB domain and leucine zipper motif antibody,AKT2INTERACTOR antibody,APPL 1 antibody,APPL1 antibody,DCC interacting protein 13 alpha antibody,DIP 13 alphaantibody,DIP13 alpha antibody,DIP13alpha antibody,KIAA1428 antibody,PTB domain and leucine zipper motif 1antibody,PTB Domain and Leucine Zipper Motif antibody,Signaling adaptor protein DIP13alphaantibody
UniProt Q8K3H0
Application Notes Optimal antibody dilution should be determined by titration, however as a guideline try, WB: 1/500. ICC/IF: 1/500.

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus

Restrictions For Research Use only
Format Liquid
Buffer 0.1 % sodium azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
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 image for anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) antibody (ABIN1042584) anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) antibody
Product cited in: Mackrell, Arias, Cartee: "Fiber type-specific differences in glucose uptake by single fibers from skeletal muscles of 9- and 25-month-old rats." in: The journals of gerontology. Series A, Biological sciences and medical sciences, Vol. 67, Issue 12, pp. 1286-94, 2012 (PubMed).

Mackrell, Cartee: "A novel method to measure glucose uptake and myosin heavy chain isoform expression of single fibers from rat skeletal muscle." in: Diabetes, Vol. 61, Issue 5, pp. 995-1003, 2012 (PubMed).

Sharma, Arias, Bhat et al.: "Mechanisms for increased insulin-stimulated Akt phosphorylation and glucose uptake in fast- and slow-twitch skeletal muscles of calorie-restricted rats." in: American journal of physiology. Endocrinology and metabolism, Vol. 300, Issue 6, pp. E966-78, 2011 (PubMed).

Sharma, Arias, Sajan et al.: "Insulin resistance for glucose uptake and Akt2 phosphorylation in the soleus, but not epitrochlearis, muscles of old vs. adult rats." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 108, Issue 6, pp. 1631-40, 2010 (PubMed).

Mitsuuchi, Johnson, Sonoda et al.: "Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2." in: Oncogene, Vol. 18, Issue 35, pp. 4891-8, 1999 (PubMed).

Catalog No. ABIN1042584
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