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Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) antibody

Details for Product No. ABIN1042584
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Antigen
Synonyms APPL, DIP13alpha, 2900057D21Rik, 7330406P05Rik, AI585782, AW209077, BB022931, C88264, DIP13, RGD1309388
Reactivity
Mouse (Murine), Rat (Rattus), Human
(48), (32), (18), (15), (14), (12)
Host
Rabbit
(42), (6), (3)
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunoprecipitation (IP), Western Blotting (WB), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(41), (20), (10), (7), (6), (4), (2), (2), (1), (1)
Pubmed 2 references available
Quantity 50 µL
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Catalog No. ABIN1042584
576.05 $
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Immunogen Purified APPL fusion
Clone N-A
Cross-Reactivity Mouse (Murine)
Characteristics Predicted molecular weight: 80 kDa.
Purification Unpurified
Alternative Name APPL1
Background Synonyms:
Adaptor Protein Containing pH Domain antibody,Adaptor protein containing pH domain PTB domain and leucinezipper motif 1 antibody,Adaptor protein containing pH domain PTB domain and leucine zipper motif antibody,AKT2INTERACTOR antibody,APPL 1 antibody,APPL1 antibody,DCC interacting protein 13 alpha antibody,DIP 13 alphaantibody,DIP13 alpha antibody,DIP13alpha antibody,KIAA1428 antibody,PTB domain and leucine zipper motif 1antibody,PTB Domain and Leucine Zipper Motif antibody,Signaling adaptor protein DIP13alphaantibody
UniProt Q8K3H0
Application Notes Optimal antibody dilution should be determined by titration, however as a guideline try, WB: 1/500. ICC/IF: 1/500.
Comment

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus

Restrictions For Research Use only
Format Liquid
Buffer 0.1 % sodium azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Supplier Images
anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) antibody anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) antibody
Product cited in: Mitsuuchi, Johnson, Sonoda et al.: "Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2." in: Oncogene, Vol. 18, Issue 35, pp. 4891-8, 1999 (PubMed).

Sharma, Arias, Sajan et al.: "Insulin resistance for glucose uptake and Akt2 phosphorylation in the soleus, but not epitrochlearis, muscles of old vs. adult rats." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 108, Issue 6, pp. 1631-40, 2010 (PubMed).

Validation Images
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