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Details for Product No. ABIN1042584

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) antibody

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Antigen
Synonyms APPL, DIP13alpha, 2900057D21Rik, 7330406P05Rik, AI585782, AW209077, BB022931, C88264, DIP13, RGD1309388
Reactivity
»Alternatives Mouse (Murine), Rat (Rattus), Human
Host
»Alternatives Rabbit
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives Immunoprecipitation (IP), Western Blotting (WB), Immunocytochemistry (ICC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
Pubmed 2 references available
Catalog no. ABIN1042584
Quantity 50 ┬ÁL
Price
576.05 $   Plus shipping costs $45.00
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Availability Will be delivered in 5 to 6 Business Days
Immunogen Purified APPL fusion
Cross-Reactivity Mouse (Murine)
Characteristics Rabbit Anti-APPL1
Purification Unpurified
Alternative Name APPL1
Molecular Weight 80 kDa
Gene ID 290537
OMIM 604299
UniProt Q8K3H0
Application Notes Optimal antibody dilution should be determined by titration, however as a guideline try WB: 1/500.
Comment

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus

Restrictions For Research Use only
Format Liquid
Buffer Unpurified antiserum containing 0.1% sodium azide
Preservative Sodium azide
Product cited in: Mitsuuchi, Johnson, Sonoda et al.: "Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2." in: Oncogene, Vol. 18, Issue 35, pp. 4891-8, 1999 (PubMed).

Sharma, Arias, Sajan et al.: "Insulin resistance for glucose uptake and Akt2 phosphorylation in the soleus, but not epitrochlearis, muscles of old vs. adult rats." in: Journal of applied physiology (Bethesda, Md. : 1985), Vol. 108, Issue 6, pp. 1631-40, 2010 (PubMed).

Alternatives for antigen "Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1)", type "Antibodies"
Hosts (35), (6), (2)
Reactivities (39), (28), (16), (15), (13), (12)
Applications (33), (21), (10), (7), (4), (2), (2), (1), (1)
Conjugates (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Epitopes (10), (2), (1), (1), (1), (1), (1), (1)
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