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Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) antibody

Antigen

Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1)
Synonyms APPL, DIP13alpha
Host
Alternatives

Rabbit
Reactivity
Alternatives

Human
Conjugate
Alternatives Un-conjugated
Application
Alternatives Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
1 reference available
Catalog no. ABIN1042584
Quantity 50ul
Price 411.05 $   Plus shipping costs $45.00
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anti-Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1) antibody

Additional Information
Application Details Publications Images Alternatives back to top

Alternative name APPL1
Immunogen Purified APPL fusion
Cross-Reactivity Mouse (Murine)
Format Liquid
Description Synonyms: Adaptor Protein Containing pH Domain antibody,Adaptor protein containing pH domain PTB domain and leucinezipper motif 1 antibody,Adaptor protein containing pH domain PTB domain and leucine zipper motif antibody,AKT2INTERACTOR antibody,APPL 1 antibody,APPL1 antibody,DCC interacting protein 13 alpha antibody,DIP 13 alphaantibody,DIP13 alpha antibody,DIP13alpha antibody,KIAA1428 antibody,PTB domain and leucine zipper motif 1antibody,PTB Domain and Leucine Zipper Motif antibody,Signaling adaptor protein DIP13alphaantibody
Specificity Human and Mouse APPL1.
Comments

The protein encoded by this gene has been shown to be involved in the regulation of cell proliferation, and in the crosstalk between the adiponectin signalling and insulin signalling pathways. The encoded protein binds many other proteins, including RAB5A, DCC, AKT2, PIK3CA, adiponectin receptors, and proteins of the NuRD/MeCP1 complex. This protein is found associated with endosomal membranes, but can be released by EGF and translocated to the nucleus

Application Details
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Application Notes Optimal antibody dilution should be determined by titration, however as a guideline try 1:500
Purification Unpurified antiserum
Restrictions For Research Use only

Publications
Application Details Images Alternatives back to top

Product Mitsuuchi, Johnson, Sonoda et al.: "Identification of a chromosome 3p14.3-21.1 gene, APPL, encoding an adaptor molecule that interacts with the oncoprotein-serine/threonine kinase AKT2." in: Oncogene, Vol. 18, Issue 35, pp. 4891-8, 1999 (PubMed).

Alternatives
Application Details Publications Images back to top

Alternatives for antigen "Adaptor Protein, phosphotyrosine Interaction, PH Domain and Leucine Zipper Containing 1 (APPL1)", type "Antibodies"
Hosts Rabbit (34), Goat (5)
Reactivities Human (35), Mouse (Murine) (26), Rat (Rattus) (24), Cow (Bovine) (21), Dog (Canine) (19), Horse (Equine) (18), Pig (Porcine) (18), Cat (Feline) (1), Chicken (1)
Applications Western Blotting (WB) (23), Immunofluorescence (IF) (19), ELISA (15), Immunohistochemistry (IHC) (7), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) (6), Immunoprecipitation (IP) (4), Immunohistochemistry (Formalin-fixed Sections) (IHC (f)) (3), Immunoelectron Microscopy (IEM) (1)
Conjugates Alexa Fluor 350 (1), Alexa Fluor 488 (1), Alexa Fluor 555 (1), Alexa Fluor 647 (1), Biotin (1), Cy3 (1), Cy5 (1), Cy5.5 (1), Cy7 (1), FITC (1), Gold (1), HRP (1), PE (1), PE,Cy3 (1), PE,Cy5 (1), PE,Cy5.5 (1), PE,Cy7 (1)
Epitopes C-Term (2), Internal Region (2)