PLA2G2A antibody (AA 21-144)

Catalog No. ABIN1045950

Product Details anti-PLA2G2A Antibody

Target: PLA2G2A (Phospholipase A2, Group IIA (Platelets, Synovial Fluid) (PLA2G2A))

Binding Specificity: AA 21-144

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This PLA2G2A antibody is un-conjugated

Application: ELISA, Immunohistochemistry (IHC)

Cross-Reactivity: Human

Purification: >95%, Protein G purified

Immunogen: Recombinant Human Phospholipase A2, membrane associated protein (21-144AA)

Isotype: IgG

Application Details

Application Notes: Recommended dilution: IHC:1:20-1:200,

Restrictions: For Research Use only

Handling

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Preservative: ProClin

Precaution of Use: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Handling Advice: Avoid freeze and thaw cycles.

Storage: -20 °C,-80 °C

Storage Comment: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Target Details for PLA2G2A

Target: PLA2G2A (Phospholipase A2, Group IIA (Platelets, Synovial Fluid) (PLA2G2A))

Alternative Name: PLA2G2A (PLA2G2A Products)

Synonyms: MOM1 antibody, PLA2 antibody, PLA2B antibody, PLA2L antibody, PLA2S antibody, PLAS1 antibody, sPLA2 antibody, EF antibody, Mom1 antibody, Pla2 antibody, sPla2-IIA antibody, phospholipase A2 group IIA antibody, phospholipase A2, group IIA (platelets, synovial fluid) antibody, PLA2G2A antibody, Pla2g2a antibody

Background:

Background: Catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides (PubMed:2925633). Thought to participate in the regulation of phospholipid metabolism in biomembranes including eicosanoid biosynthesis. Independent of its catalytic activity, acts as a ligand for integrins (PubMed:18635536, PubMed:25398877). Binds to and activates integrins ITGAV:ITGB3, ITGA4:ITGB1 and ITGA5:ITGB1 (PubMed:18635536, PubMed:25398877). Binds to a site (site 2) which is distinct from the classical ligand-binding site (site 1) and induces integrin conformational changes and enhanced ligand binding to site 1 (PubMed:25398877). Induces cell proliferation in an integrin-dependent manner (PubMed:18635536).

Aliases: EC 3.1.1.4 antibody, GIIC sPLA2 antibody, Group IIA phospholipase A2 antibody, membrane associated antibody, Modifier of MIN 1 mouse homolog antibody, MOM1 antibody, Non-pancreatic secretory phospholipase A2 antibody, NPS PLA2 antibody, NPS-PLA2 antibody, PA2GA_HUMAN antibody, Phosphatidylcholine 2-acylhydrolase 2A antibody, Phosphatidylcholine 2acylhydrolase antibody, Phospholipase A2 antibody, Phospholipase A2 group IIA (platelets, synovial fluid) antibody, Phospholipase A2 membrane associated antibody, Phospholipase A2 polypeptide B antibody, Phospholipase A2 synovial antibody, PLA2 antibody, PLA2B antibody, PLA2G2A antibody, PLA2L antibody, PLA2S antibody, PLAS1 antibody, RASF A antibody, sPLA2 antibody

UniProt: P14555

Pathways: Stem Cell Maintenance, Inositol Metabolic Process