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Seryl-tRNA Synthetase (SARS) (AA 2-233) antibody (HRP)

SARS Reactivity: Human ELISA Host: Rabbit Polyclonal HRP
Catalog No. ABIN1046072
  • Target See all Seryl-tRNA Synthetase (SARS) Antibodies
    Seryl-tRNA Synthetase (SARS)
    Binding Specificity
    • 5
    • 3
    • 3
    • 2
    • 1
    • 1
    AA 2-233
    Reactivity
    • 27
    • 13
    • 13
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    Human
    Host
    • 25
    • 2
    Rabbit
    Clonality
    • 26
    • 1
    Polyclonal
    Conjugate
    • 16
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    HRP
    Application
    • 17
    • 8
    • 8
    • 4
    • 3
    • 1
    • 1
    • 1
    ELISA
    Cross-Reactivity
    Human
    Purification
    >95%, Protein G purified
    Immunogen
    Recombinant Human Serine--tRNA ligase, cytoplasmic protein (2-233AA)
    Isotype
    IgG
    Top Product
    Discover our top product SARS Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Buffer
    Preservative: 0.03 % Proclin 300
    Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4
    Preservative
    ProClin
    Precaution of Use
    This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
    Handling Advice
    Avoid freeze and thaw cycles.
    Do NOT add Sodium Azide! Use of Sodium Azide will inhibit enzyme activity of horseradish peroxidase.
    Storage
    -20 °C,-80 °C
    Storage Comment
    Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
  • Target
    Seryl-tRNA Synthetase (SARS)
    Alternative Name
    SARS (SARS Products)
    Synonyms
    SERRS antibody, SERS antibody, Sars1 antibody, Strs antibody, serRS antibody, SerRS antibody, wu:fk51f08 antibody, zgc:92152 antibody, seryl-tRNA synthetase antibody, seryl-aminoacyl-tRNA synthetase antibody, SARS antibody, Sars antibody, sars antibody
    Background

    Background: Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at \\\'Lys-16\\\' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000).

    Aliases: C78314 antibody, cytoplasmic antibody, EC 6.1.1.11 antibody, FLJ36399 antibody, sarS antibody, Sars1 antibody, Serine tRNA ligase 1, cytoplasmic antibody, Serine tRNA ligase antibody, Serine--tRNA ligase antibody, serine--tRNA ligase, cytoplasmic antibody, SerRS antibody, SERS antibody, Seryl tRNA Ser/Sec synthetase antibody, Seryl tRNA synthetase antibody, Seryl tRNA synthetase cytoplasmic antibody, Seryl-tRNA Ser/Sec synthetase antibody, Seryl-tRNA synthetase antibody, seryl-tRNA synthetase, cytoplasmic antibody, Seryl-tRNA(Ser/Sec) synthetase antibody, Strs antibody, SYSC_HUMAN antibody

    UniProt
    P49591
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