p65 antibody (Nuclear Factor-KB P65) (pSer529)

Details for Product anti-NFkBP65 Antibody No. ABIN105287, Supplier: Log in to see
Antigen
  • NFKB3
  • p65
  • NFkB
  • v-rel avian reticuloendotheliosis viral oncogene homolog A
  • v-rel reticuloendotheliosis viral oncogene homolog A (avian)
  • RELA
  • Rela
Alternatives
anti-Human p65 antibody for BioImaging
Epitope
pSer529
137
72
65
58
51
47
43
40
39
36
33
32
25
21
18
17
16
15
15
13
13
13
12
11
10
9
9
8
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6
4
4
4
4
4
3
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human
1207
677
519
73
59
55
31
30
28
25
15
8
8
6
5
4
2
1
1
Host
Rabbit
1036
147
17
16
11
1
Clonality
Polyclonal
Conjugate
This p65 antibody is un-conjugated
34
34
26
21
19
18
16
16
13
13
13
9
9
9
9
9
9
8
8
4
4
3
3
3
2
2
2
2
2
2
1
Application
Immunoprecipitation (IP), Immunohistochemistry (IHC), ELISA, Western Blotting (WB)
880
428
356
269
224
148
118
88
84
28
22
19
18
11
11
6
6
6
5
4
4
2
2
1
Options
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Immunogen NFkB p65 (Rel A) peptide corresponding to a region near phospho Serine 529 of the human protein conjugated to Keyhole Limpet Hemocyanin (KLH).
Characteristics Concentration Definition: by Refractometry
Purification Antiserum
Alternative Name NFkB p65 (RelA) (NFkBP65 Antibody Abstract)
Background NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. Anti-NFkB antibody is ideal for Cell Biology, Nuclear Signaling, Neuroscience and Signal Transduction Research
Synonyms: NFKB, nfkb, NF-kB, NF-kappaB, NFkappaB
Gene ID 5970, 223468676
UniProt Q04206
Pathways NF-kappaB Signaling, RTK Signaling, TCR Signaling, TLR Signaling, Fc-epsilon Receptor Signaling Pathway, Neurotrophin Signaling Pathway, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Hepatitis C, Toll-Like Receptors Cascades
Application Notes Anti-phospho NFkB antibody reacts human pS529 p65 and shows minimal reactivity by western blot with non-phosphorylated p65 and minimal reactivity by ELISA against the non-phosphorylated form of the immunizing peptide.  Although not tested, this antibody is likely functional in immunohistochemistry and immunoprecipitation.
Restrictions For Research Use only
Format Liquid
Concentration 75 mg/mL
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage -20 °C
Supplier Images
Western Blotting (WB) image for anti-p65 antibody (Nuclear Factor-KB P65) (pSer529) (ABIN105287) TNF Induces phosphorylation of p65 in KBM-5 cells.  Cytoplasmic and nuclear protein l...
Western Blotting (WB) image for anti-p65 antibody (Nuclear Factor-KB P65) (pSer529) (ABIN105287) anti-Nuclear Factor-KB P65 (NFkBP65) (pSer529) antibody (Image 2)
 image for anti-p65 antibody (Nuclear Factor-KB P65) (pSer529) (ABIN105287) anti-Nuclear Factor-KB P65 (NFkBP65) (pSer529) antibody (Image 3)
 image for anti-p65 antibody (Nuclear Factor-KB P65) (pSer529) (ABIN105287) anti-Nuclear Factor-KB P65 (NFkBP65) (pSer529) antibody (Image 4)
Product cited in: Gavert, Ben-Shmuel, Lemmon, Brabletz, Ben-Zeev: "Nuclear factor-kappaB signaling and ezrin are essential for L1-mediated metastasis of colon cancer cells." in: Journal of cell science, Vol. 123, Issue Pt 12, pp. 2135-43, 2010 (PubMed).

Amith, Jayanth, Franchuk, Finlay, Seyrantepe, Beyaert, Pshezhetsky, Szewczuk: "Neu1 desialylation of sialyl alpha-2,3-linked beta-galactosyl residues of TOLL-like receptor 4 is essential for receptor activation and cellular signaling." in: Cellular signalling, 2009 (PubMed).

Shakibaei, John, Schulze-Tanzil, Lehmann, Mobasheri et al.: "Suppression of NF-kappaB activation by curcumin leads to inhibition of expression of cyclo-oxygenase-2 and matrix metalloproteinase-9 in human articular chondrocytes: Implications for the treatment ..." in: Biochemical pharmacology, Vol. 73, Issue 9, pp. 1434-45, 2007 (PubMed).

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