LMX1B antibody (C-Term)

Catalog No. ABIN1077396

Product Details anti-LMX1B Antibody

Target: LMX1B (LIM Homeobox Transcription Factor 1, beta (LMX1B))

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This LMX1B antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Specificity: At least three isoforms are known to exist. This antibody is predicted to not cross-react with LMX1A.

Purification: Affinity chromatography purified via peptide column

Immunogen: Rabbit polyclonal LMX1B antibody was raised against a 17 amino acid peptide near the carboxy terminus of human LMX1B.

Isotype: IgG

Application Details

Application Notes: LMX1B antibody can be used for detection of LMX1B by Western blot at 1 - 2 μg/mL. For immunofluorescence start at 20 μg/mL.

Comment:

(CT) LIM homeobox transcription factor 1 beta

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C/-20 °C

Storage Comment: LMX1B antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Expiry Date: 12 months

Target Details for LMX1B

Target: LMX1B (LIM Homeobox Transcription Factor 1, beta (LMX1B))

Alternative Name: LMX1B (LMX1B Products)

Synonyms: LMX1.2 antibody, NPS1 antibody, LMX antibody, LMX1 antibody, LMX1.1 antibody, lmx1b antibody, lmx1b.1 antibody, Xlmx1b antibody, lmx1b.2 antibody, LIM homeobox transcription factor 1 beta antibody, LIM homeobox transcription factor 1, beta b antibody, LIM homeobox transcription factor 1, beta, gene 1 S homeolog antibody, LIM homeobox transcription factor 1, beta a antibody, LMX1B antibody, Lmx1b antibody, lmx1bb antibody, lmx1b.1.S antibody, lmx1ba antibody

Background: The LIM homeobox transcription factor 1B (LMX1B) belongs to the LIM-homeodomain family. Members of this family are known to be important for pattern formation during development. LMX1B regulates mid-hindbrain patterning, LMX1B-null mice embryos have a severe reduction in the number of midbrain dopaminergic neurons compared to wild-type. While LMX1B appears to be important for both the development and the survival of dopamine neurons, the related LMX1A is crucial for the differentiation of these cells. However, LMX1A and LMX1B function cooperatively to regulated the proliferation, specification and differentiation of midbrain dopaminergic neuronal progenitors.
Synonyms: LIM homeobox transcription factor 1 beta, LIM/homeobox protein LMX1B, LIM/homeobox protein 1.2

Molecular Weight: 45 kDa

Gene ID: 4010

NCBI Accession: NP_001167617

Pathways: Dopaminergic Neurogenesis