Prostaglandin D2 Receptor 2 (PTGDR2) antibody

Catalog No. ABIN1077429

Product Details

Target: Prostaglandin D2 Receptor 2 (PTGDR2)

Reactivity: Human, Mouse

Host: Rabbit

Clonality: Monoclonal

Conjugate: Un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogen: Rabbit polyclonal PTGDR2 antibody was raised against a 19 amino acid peptide near the center of human PTGDR2.

Isotype: IgG

Application Details

Application Notes: PTGDR2 antibody can be used for detection of PTGDR2 by Western blot at 0.5 - 1 μg/mL.

Comment:

(IN) Prostaglandin D2 receptor 2

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C

Storage Comment: PTGDR2 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Expiry Date: 12 months

Target Details

Target: Prostaglandin D2 Receptor 2 (PTGDR2)

Alternative Name: PTGDR2 (PTGDR2 Products)

Synonyms: CD294 antibody, CRTH2 antibody, DL1R antibody, DP2 antibody, GPR44 antibody, Crth2 antibody, Grp45 antibody, Ptgdr2 antibody, Gpr44 antibody, prostaglandin D2 receptor 2 antibody, PTGDR2 antibody, Ptgdr2 antibody

Background: The prostaglandin D2 receptor 2 (PTGDR2), also known as CRTH2, is expressed on Th2 cells and eosinophils and mediates chemotaxis of these cells to PGD2 and is thus thought to be a key receptor mediating eosinophil and Th2 recruitment during allergic responses. However, PTGDR2-null mice showed enhanced eosinophil recruitment into the lung consistent with observations that the PTGDR2-null mice produced significantly higher amounts of interleukin-5 (IL-5) and IL-3. This suggests that PTGDR2 plays a nonredundant role in restricting eosinophilia and allergic response in vivo.
Synonyms: Prostaglandin D2 receptor 2, chemoattractant receptor-homologous molecule expressed on Th2 cells, CRTH2, G protein-coupled receptor 44, GPR44, CD294, DL1R, DP2

Molecular Weight: 43 kDa (calculated)

Gene ID: 11251

NCBI Accession: NP_004769

Pathways: Regulation of G-Protein Coupled Receptor Protein Signaling