Cyclin T1 antibody (C-Term)

Catalog No. ABIN1077437

Product Details anti-Cyclin T1 Antibody

Target: Cyclin T1 (CCNT1)

Binding Specificity: C-Term

Reactivity: Human, Mouse, Rat

Host: Rabbit

Clonality: Polyclonal

Conjugate: This Cyclin T1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA

Purification: Affinity chromatography purified via peptide column

Immunogen: Rabbit polyclonal CCNT1 antibody was raised against an 18 amino acid peptide near the carboxy terminus of human CCNT1.

Isotype: IgG

Application Details

Application Notes: CCNT1 antibody can be used for detection of CCNT1 by Western blot at 1 - 2 μg/mL.

Comment:

(CT) Cyclin T1

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: PBS containing 0.02 % Sodium azide.

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Storage: 4 °C

Storage Comment: CCNT1 antibody can be stored at 4 °C for three months. At -20 °C stable for up to one year.

Expiry Date: 12 months

Target Details for Cyclin T1

Target: Cyclin T1 (CCNT1)

Alternative Name: CCNT1 (CCNT1 Products)

Synonyms: CG6292 antibody, Dmcyclin T antibody, Dmel\\CG6292 antibody, ORE-14 antibody, P-TEFb antibody, anon-74EFc antibody, dT antibody, p124 antibody, Cyclin-T1 antibody, ccnt antibody, cyct1 antibody, CCNT antibody, CYCT1 antibody, HIVE1 antibody, 2810478G24Rik antibody, AI115585 antibody, CycT1 antibody, fi75b02 antibody, si:dkey-18f23.10 antibody, wu:fi75b02 antibody, Cyclin T antibody, cyclin T1 antibody, cyclin T1 L homeolog antibody, CycT antibody, CCNT1 antibody, ccnt1 antibody, Ccnt1 antibody, ccnt1.L antibody

Background: Cyclins function as regulators of CDK kinases and exhibit distinct expression and degradation patterns which contribute to the temporal coordination of each mitotic event. The cyclin-T1 protein (CCNT1) belongs to the highly conserved cyclin family, whose members are characterized by a dramatic periodicity in protein abundance through the cell cycle. CCNT1 tightly associates with CDK9 kinase, and was found to be a major subunit of the transcription elongation factor p-TEFb. The kinase complex containing CCNT1 and the elongation factor can interact with, and act as a cofactor of human immunodeficiency virus type 1 (HIV-1) Tat protein, and was shown to be both necessary and sufficient for full activation of viral transcription. CCNT1 and its kinase partner were also found to be involved in the phosphorylation and regulation of the carboxy-terminal domain (CTD) of the largest RNA polymerase II subunit.
Synonyms: Cyclin T1, cyclin-T1, CDK9-associated C-type protein, human immunodeficiency virus type 1 expression 1, HIVE1

Molecular Weight: 80 kDa (calculated)

Gene ID: 904

NCBI Accession: NP_001231