Cardiotrophin 1 (CTF1) antibody

Antigen: Cardiotrophin 1 (CTF1)

Synonyms: CT1, CT-1, CTF1, ct1, ct-1, ctf2

Clonality: Monoclonal (1F3)

Host: Mouse

Reactivity: Human

Application: ELISA, Western Blotting (WB)

Catalog no.: ABIN108472

Additional Information

Alternative name: Cardiotrophin 1

Format: Affinity-purified

Isotype: IgG1  (Matching secondary antibodies)

Clone: 1F3

Description: Specification: Anti-Human Cardiotrophin-1 Mouse Monoclonal Antibody, Clone: 1F3 is the antibody against human cardiotrophin-1. The Human Cardiotrophin is created as a recombinant protein with N-terminal fusion of His-Tag, is 22.5 kDa protein containing 200 amino acid residues of the human cardiotrophin and 12 additional amino acid residues (underlined). The amino acid sequence of the recombinant human cardiotrophin is 100% homologous to the amino acid sequence of the human cardiotrophin.

Application Details

Application Notes: Titre: Is defined by indirect ELISA, it is >1/100,000 for antibody concentration 1mg/ml, 25 ng of antigen are coated per well, and is then defined at a point of maximal decrease of the titration curve.

Storage: Store lyophilized antibody at 2-8°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles and store frozen at -80°C. Reconstituted antibody can be stored at 4°C for a limited period of time, it does not show decline in activity after two weeks at 4°C.

Research Area: Growth Factors

Restrictions: For Research Use only

Publications

Publications: Talwar S, Squire IB, O'brien RJ et al.: "Plasma cardiotrophin-1 following acute myocardial infarction: relationship with left ventricular systolic dysfunction." in: Clin Sci (Lond), Vol. 102, Issue 1, pp. 9-14, 2002 (PubMed).

Shioji K, Kishimoto C, Nakamura H et al.: "Overexpression of thioredoxin-1 in transgenic mice attenuates adriamycin-induced cardiotoxicity." in: Circulation, Vol. 106, Issue 11, pp. 1403-9, 2002 (PubMed).

Freed DH, Borowiec AM, Angelovska T et al.: "Induction of protein synthesis in cardiac fibroblasts by cardiotrophin-1: integration of multiple signaling pathways." in: Cardiovasc Res, Vol. 60, Issue 2, pp. 365-75, 2003 (PubMed).

Freed DH, Moon MC, Borowiec AM et al.: "Cardiotrophin-1: expression in experimental myocardial infarction and potential role in post-MI wound healing." in: Mol Cell Biochem, Vol. 254, Issue 1-2, pp. 247-56, 2003 (PubMed).