Clara Cell Phospholipid-Binding Protein (SCGB1A1) antibody

Details for Product No. ABIN108510
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ELISA, Immunohistochemistry (IHC), Western Blotting (WB)
(1), (1), (1), (1)
Pubmed 7 references available
Quantity 0.1 mg
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  • The antibody was raised in rabbits by immunization with the Human Clara Cell Protein.
  • Source of Immunogen: Human urine
Isotype IgG1
No Cross-Reactivity Human
Cross-Reactivity (Details) Not yet tested in other species.
Purification Immunoaffinity chromatography on a column with immobilized Human Clara Cell Protein.
Alternative Name Clara Cell Protein
  • Human Clara Cell Protein (CC16, CC10 and also called uteroglobin, urinary protein 1 or Clara Cell Secretory Protein) belongs to the family of secretoglobins and is a secreted protein product of non-ciliated bronchiolar Clara cells. Its function remains to be elucidated but there is convincing data suggesting its phospholipase A2 inhibitory activity as well as a number of other immunomodulatory features including inhibition of interferon gamma signaling and Th1 vs. Th2 lymphocyte regulation. It was proposed as a potential peripheral marker of respiratory epithelial injury and bronchial dysfunction. In serum, its increase is associated with age, asbestos, nitrogen chloride and ozone exposure, sarcoidosis and high PEEP ventilation. Decreased serum CC16 levels are found after pulmonary resection, in silica-exposed workers, smokers and in asthma. Decreased CC16 concentrations were also found in the amniotic fluid of fetuses suffering from pulmonary hypoplasia caused by various mechanisms (diaphragmatic hernia, diabetic fetopathy, Turner and Down syndrome).
Application Notes
  • Quality control: Indirect ELISA - to determine titer of the antibody SDS PAGE - to determine purity of the antibody
  • Otimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Lyophilized
Reconstitution Add 0.1 mL of deionized water and let the lyophilized pellet dissolve completely. Slight turbidity may occur after reconstitution, which does not affect activity of the antibody. In this case clarify the solution by centrifugation
Buffer The antibody is lyophilized in 0.05 M phosphate buffer, 0.1 M NaCl, pH 7.2. AZIDE FREE.
Preservative Azide free
Storage 4 °C/-20 °C/-80 °C
Storage Comment The lyophilized antibody remains stable and fully active until the expiry date when stored at -20 °C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles and store frozen at -80 °C. Reconstituted antibody can be stored at 4 °C for a limited period of time, it does not show decline in activity after one week at 4 °C.
Expiry Date See label
General Petrek M, Hermans C, Kolek V et al.: "Clara cell protein (CC16) in serum and bronchoalveolar lavage fluid of subjects exposed to asbestos." in: Biomarkers, Vol. 7, Issue 1, pp. 58-67, 2002 (PubMed).

Nord, Schubert, Cassel et al.: "Decreased serum and bronchoalveolar lavage levels of Clara cell secretory protein (CC16) is associated with bronchiolitis obliterans syndrome and airway neutrophilia in lung transplant recipients." in: Transplantation, Vol. 73, Issue 8, pp. 1264-9, 2002 (PubMed).

Hermans C, Petrek M, Kolek V et al.: "Serum Clara cell protein (CC16), a marker of the integrity of the air-blood barrier in sarcoidosis." in: Eur Respir J, Vol. 18, Issue 3, pp. 507-14, 2001 (PubMed).

Broeckaert, Clippe, Knoops et al.: "Clara cell secretory protein (CC16): features as a peripheral lung biomarker." in: Annals of the New York Academy of Sciences, Vol. 923, pp. 68-77, 2001 (PubMed).

Linnoila, Szabo, DeMayo et al.: "The role of CC10 in pulmonary carcinogenesis: from a marker to tumor suppression." in: Annals of the New York Academy of Sciences, Vol. 923, pp. 249-67, 2001 (PubMed).

Jackson, Turner, Keen et al.: "Purification and partial amino acid sequence of human urine protein 1. Evidence for homology with rabbit uteroglobin." in: Journal of chromatography, Vol. 452, pp. 359-67, 1989 (PubMed).

Bernard, Roels, Lauwerys et al.: "Human urinary protein 1: evidence for identity with the Clara cell protein and occurrence in respiratory tract and urogenital secretions." in: Clinica chimica acta, international journal of clinical chemistry, Vol. 207, Issue 3, pp. 239-49, 1992 (PubMed).

Catalog No. ABIN108510
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