sRANK antibody

Antigen: sRANK

Clonality: Polyclonal

Host: Rabbit

Reactivity: Human

Application: ELISA, Western Blotting (WB)

Certificates: ISO 9001:2008, ISO 13485:2003

Catalog no.: ABIN108528

Additional Information

Format: Affinity-purified

Description: Specification: Anti-Human RANK Antibody was raised in rabbit against recombinant human RANK. Human RANK is a soluble 19.3 kDa protein containing 175 amino acid residues, comprising of the full-length of the TNF receptor-like extracellular domain of RANK receptor

Application Details

Application Notes: Titre: Is defined by indirect ELISA, it is >1/100,000 for antibody concentration 1mg/ml, 25 ng of antigen are coated per well, and is then defined at a point of maximal decrease of the titration curve.

Storage: Store lyophilized antibody at 2-8°C. Aliquot the product after reconstitution to avoid repeated freezing/thawing cycles and store frozen at -80°C. Reconstituted antibody can be stored at 4°C for a limited period of time, it does not show decline in activity after two weeks at 4°C.

Restrictions: For Research Use only

Publications

Nakagawa, Kinosaki, Yamaguchi et al.: "RANK is the essential signaling receptor for osteoclast differentiation factor in osteoclastogenesis." in: Biochemical and biophysical research communications, Vol. 253, Issue 2, pp. 395-400, 1999 (PubMed).

Li J, Sarosi I, Yan XQ et al.: "RANK is the intrinsic hematopoietic cell surface receptor that controls osteoclastogenesis and regulation of bone mass and calcium metabolism." in: Proc Natl Acad Sci U S A, Vol. 97, Issue 4, pp. 1566-71, 2000 (PubMed).

Prochownik EV, Kirsten WH: "Nucleic acid sequences of primate type C viruses in normal and neoplastic human tissues." in: Nature, Vol. 267, Issue 5607, pp. 175-7, 1977 (PubMed).