SMN1 antibody

Catalog No. ABIN108567

Product Details anti-SMN1 Antibody

Target: SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))

Reactivity: Human, Mouse, Xenopus laevis

Host: Mouse

Clonality: Monoclonal

Conjugate: This SMN1 antibody is un-conjugated

Application: Western Blotting (WB), ELISA, Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Flow Cytometry (FACS)

Purification: Protein A

Immunogen: Purified recombinant His 6 tagged-SMN protein (human)

Clone: 2B1

Isotype: IgG1

Application Details

Application Notes: Optimal antibody dilution should be determined by titration, however as a guideline try at IHC-P: Use a concentration of 5 μg/mL. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocolWB: Use at an assay dependent dilution. Detects a band of approximately 42 kDa (predicted molecular weight: 35 kDa)Flow Cyt: Use 1 μg for 106 cells.

Comment:

Myeloma, fusion partners: A/J Sp2/0 cell line,

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: 1 mg/mL

Buffer: Purified antibody (from supernatant) containing PBS 0.1 % sodium azide,

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

References for anti-SMN1 antibody (ABIN108567)

Grondard, Biondi, Armand, Lécolle, Della Gaspera, Pariset, Li, Gallien, Vidal, Chanoine, Charbonnier: "Regular exercise prolongs survival in a type 2 spinal muscular atrophy model mouse." in: The Journal of neuroscience : the official journal of the Society for Neuroscience, Vol. 25, Issue 33, pp. 7615-22, (2005) (PubMed).

Liu, Dreyfuss: "A novel nuclear structure containing the survival of motor neurons protein." in: The EMBO journal, Vol. 15, Issue 14, pp. 3555-65, (1996) (PubMed).

Target Details for SMN1

Target: SMN1 (Survival of Motor Neuron 1, Telomeric (SMN1))

Alternative Name: Gemin 1 (SMN1 Products)

Synonyms: SMN2 antibody, Smn antibody, SMN antibody, BCD541 antibody, GEMIN1 antibody, SMA antibody, SMA1 antibody, SMA2 antibody, SMA3 antibody, SMA4 antibody, SMA@ antibody, SMNT antibody, T-BCD541 antibody, TDRD16A antibody, AI849087 antibody, Gemin1 antibody, SMN1 antibody, QtsA-10002 antibody, fa12d01 antibody, smn antibody, wu:fa12d01 antibody, survival motor neuron protein antibody, survival of motor neuron 1, telomeric antibody, survival motor neuron 1 antibody, survival of motor neuron 2, centromeric antibody, survival motor neuron protein-like antibody, survival motor neuron antibody, LOC461829 antibody, Smn1 antibody, SMN1 antibody, SMN2 antibody, LOC100348318 antibody, SMN antibody, LOC100713418 antibody, LOC100065744 antibody, LOC102176643 antibody, smn1 antibody

Background: Synonyms:
BCD541 antibody,Gemin 1 antibody,Gemin-1 antibody,Gemin1 antibody,OTTHUMP00000125198antibody,OTTHUMP00000223567 antibody,OTTHUMP00000223568 antibody,OTTHUMP00000224066antibody,OTTHUMP00000226924 antibody,SMA 1 antibody,SMA 2 antibody,SMA 3 antibody,SMA 4 antibody,SMAantibody,SMA@ antibody,SMA1 antibody,SMA2 antibody,SMA3 antibody,SMA4 antibody,SMN 1 antibody,SMNantibody,SMN-1 antibody,SMN1 antibody,SMNT antibody,Survival motor neuron protein antibody,Survival ofmotor neuron 1 (telomeric) antibody,survival of motor neuron 1 antibody,Survival of motor neuron 1, telomericantibody,T-BCD541 antibody

Gene ID: 6606, 6607, 20595

OMIM: 600354

UniProt: Q16637, P97801

Pathways: Ribonucleoprotein Complex Subunit Organization