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Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC) antibody

Details for Product No. ABIN108591
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Antigen
Synonyms MGC53243, HNRPC, AL022939, D14Wsu171e, Hnrpc, Hnrpc1, Hnrpc2, hnRNPC1, hnRNPC2, hnrnp-C, bZ1G18.4, fb57h12, fi16b11, wu:fb57h12, wu:fi16b11, zgc:55701, C1, C2, HNRNP, SNRPC, hnRNP C, HNRNPC
Reactivity
Chicken, Hamster, Human, Monkey
(47), (34), (33), (14), (12), (3), (3), (3), (3), (2), (1)
Host
Mouse
(44), (6)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), ELISA, Western Blotting (WB)
(41), (21), (20), (18), (11), (11), (10), (10), (6)
Pubmed 11 references available
Quantity 50 µL
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Catalog No. ABIN108591
504.24 $
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Immunogen RNPs eluted from oligo (dT) cellulose column
Clone 4F4
Isotype IgG1
Specificity This antibody recognizes the two hnRNP C proteins of 41 and 43kDa in human cells, and the corresponding proteins in monkey hamster chicken.
Characteristics Myeloma fusion partners:
SP2/0
Detects a band of approximately 36 kDa (predicted molecular weight: 41,43 kDa). Human nuclear HEK 293A lysate. Detects isoforms at molecular weight approximately 41,43 kDa
Purification Protein A
Alternative Name hnRNP C1+C2
Background Synonyms:
C1 antibody,C2 antibody,Heterogeneous nuclear ribonucleoprotein C antibody,Heterogeneous nuclearribonucleoproteins C1/C2 antibody,HNRNP antibody,hnRNP C1 / hnRNP C2 antibody,hnRNP C1/C2 antibody,hnRNPCantibody,HNRPC antibody,HNRPC_HUMAN antibody,MGC104306 antibody,MGC105117 antibody,MGC117353antibody,MGC131677 antibody,Nuclear ribonucleoprotein particle C1 protein antibody,Nuclear ribonucleoproteinparticle C2 protein antibody,SNRPC antibody
UniProt P07910
Application Notes Optimal antibody dilution should be determined by titration, however as a guideline try, IHC-P: Use a concentration of 1 µg/mL. Perform heat mediated antigen retrieval before commencing with IHC staining protocol. ELISA: Use at an assay dependent dilution. WB: 1/1000.
Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS, 0.1 % sodium azide
Preservative Sodium azide
Precaution of Use WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Storage 4 °C
Supplier Images
anti-Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC) antibody Western blot of hnRNP-C1/C2 on Hela extracts
anti-Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC) antibody (2) anti-Heterogeneous Nuclear Ribonucleoprotein C (C1/C2) (HNRNPC) antibody (Image 2)
Product cited in: Dreyfuss, Choi, Adam: "Characterization of heterogeneous nuclear RNA-protein complexes in vivo with monoclonal antibodies." in: Molecular and cellular biology, Vol. 4, Issue 6, pp. 1104-14, 1984 (PubMed).

Watson, Blanch, Lin et al.: "Mdm2-mediated NEDD8 modification of TAp73 regulates its transactivation function." in: The Journal of biological chemistry, Vol. 281, Issue 45, pp. 34096-103, 2006 (PubMed).

Baird, Lewis, Turcotte et al.: "A search for structurally similar cellular internal ribosome entry sites." in: Nucleic acids research, Vol. 35, Issue 14, pp. 4664-77, 2007 (PubMed).

Barrandon, Bonnet, Nguyen et al.: "The transcription-dependent dissociation of P-TEFb-HEXIM1-7SK RNA relies upon formation of hnRNP-7SK RNA complexes." in: Molecular and cellular biology, Vol. 27, Issue 20, pp. 6996-7006, 2007 (PubMed).

Kuyumcu-Martinez, Wang, Cooper: "Increased steady-state levels of CUGBP1 in myotonic dystrophy 1 are due to PKC-mediated hyperphosphorylation." in: Molecular cell, Vol. 28, Issue 1, pp. 68-78, 2007 (PubMed).

Fu, Collins: "Purification of human telomerase complexes identifies factors involved in telomerase biogenesis and telomere length regulation." in: Molecular cell, Vol. 28, Issue 5, pp. 773-85, 2007 (PubMed).

Herrmann, Pably, Eckerich et al.: "Human protein arginine methyltransferases in vivo--distinct properties of eight canonical members of the PRMT family." in: Journal of cell science, Vol. 122, Issue Pt 5, pp. 667-77, 2009 (PubMed).

Mosessian, Avliyakulov, Mulholland et al.: "Analysis of PTEN complex assembly and identification of heterogeneous nuclear ribonucleoprotein C as a component of the PTEN-associated complex." in: The Journal of biological chemistry, Vol. 284, Issue 44, pp. 30159-66, 2009 (PubMed).

Ertel, Brunner, Semler: "Mechanistic consequences of hnRNP C binding to both RNA termini of poliovirus negative-strand RNA intermediates." in: Journal of virology, Vol. 84, Issue 9, pp. 4229-42, 2010 (PubMed).

Brunner, Ertel, Rozovics et al.: "Delayed kinetics of poliovirus RNA synthesis in a human cell line with reduced levels of hnRNP C proteins." in: Virology, Vol. 400, Issue 2, pp. 240-7, 2010 (PubMed).

Nicolas, Alazard-Dany, Biollay et al.: "Identification of rep-associated factors in herpes simplex virus type 1-induced adeno-associated virus type 2 replication compartments." in: Journal of virology, Vol. 84, Issue 17, pp. 8871-87, 2010 (PubMed).

Validation Images
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