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Pregnancy Specific beta-1-Glycoprotein 5 (PSG5) antibody

Details for Product No. ABIN108731, Supplier: Log in to see
  • FL-NCA-3
  • PSG
Clonality (Clone)
Monoclonal ()
Flow Cytometry (FACS), Immunohistochemistry (IHC)
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Immunogen immunisation with extracted protein of human PSG
Clone BAP3
Isotype IgG1
Specificity BAC2 recognizes exclusively CEACAM7 transiently expressed on the cell surface of transfected BOSC23 cells. BAC2 can be used to distinguish CEACAM7 from all other CEACAM and probably all pregnancy-specific glycoprotein molecules, namely CEACAM1 (B
Purification Protein G
Alternative Name PSG (PSG5 Antibody Abstract)
Background BAP3 reacts with human pregnancy-specific glycoproteins (PSG), a group of closely related secreted glycoproteins which are highly expressed in placental syncytiotrophoblast cells of fetal origin. PSG are commonly expressed in tumors of trophoblast origin (hydatidiform mole, choriocarcinoma). They represent the most abundant fetal protein in the maternal blood at term. The eleven human PSG genes (PSG1-PSG11) form together with the carcinoembryonic antigen (CEA)-related cell adhesion molecule (CEACAM) genes the CEACAM gene family. PSG stimulates secretion of TH2-type cytokines from monocytes. CD9 was shown to represent the monocyte receptor for murine PSG17. PSG are thought to modulate the maternal immune system during pregnancy thus protecting the semiallotypic fetus from rejection.
UniProt P11464
Application Notes Flow cytometry: 1.2 µg/10^6 cells
For each application a titration should be performed to determine the optimal concentration.

Synonyms: pregnancy-specific glycoprotein 1, CD66f

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS, pH 7.2
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C
Storage Comment short term: 2 °C - 8 °C, long term: -20 °C
Supplier Images
 image for anti-Pregnancy Specific beta-1-Glycoprotein 5 (PSG5) antibody (ABIN108731) Detection of recombinant transmembrane-anchored PSG1 fusion protein on HeLa transfect...
Flow Cytometry (FACS) image for anti-Pregnancy Specific beta-1-Glycoprotein 5 (PSG5) antibody (ABIN108731) Members of the CEA family were expressed on BOSC cells after transient transfection w...
Flow Cytometry (FACS) image for anti-Pregnancy Specific beta-1-Glycoprotein 5 (PSG5) antibody (ABIN108731) FACS analysis of CHO cells using BAP3. CHO cells were transiently transfected with an...
Background publications Thomas, Zhu, Schnaar, Alves, Konstantopoulos: "Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow." in: The Journal of biological chemistry, Vol. 283, Issue 23, pp. 15647-55, 2008

Waterhouse, Ha, Dveksler: "Murine CD9 is the receptor for pregnancy-specific glycoprotein 17." in: The Journal of experimental medicine, Vol. 195, Issue 2, pp. 277-82, 2002

Beauchemin, Draber, Dveksler, Gold, Gray-Owen, Grunert, Hammarström, Holmes, Karlsson, Kuroki, Lin, Lucka, Najjar, Neumaier, Obrink, Shively, Skubitz, Stanners, Thomas, Thompson, Virji, von Kleist et al.: "Redefined nomenclature for members of the carcinoembryonic antigen family. ..." in: Experimental cell research, Vol. 252, Issue 2, pp. 243-9, 2001

Snyder, Wessner, Wessells, Waterhouse, Wahl, Zimmermann, Dveksler: "Pregnancy-specific glycoproteins function as immunomodulators by inducing secretion of IL-10, IL-6 and TGF-beta1 by human monocytes." in: American journal of reproductive immunology (New York, N.Y. : 1989), Vol. 45, Issue 4, pp. 205-16, 2001

Hammarström: "The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues." in: Seminars in cancer biology, Vol. 9, Issue 2, pp. 67-81, 1999

Zhou, Baranov, Zimmermann, Grunert, Erhard, Mincheva-Nilsson, Hammarstroem, Thompson: "Highly specific monoclonal antibody demonstrates that pregnancy-specific glycoprotein (PSG) is limited to syncytiotrophoblast in human early and term placenta." in: Placenta, Vol. 18, Issue 7, pp. 491-501, 1997

Sokolov, Kozliaeva, Mesniankina, Tatarinov: "[Isolation and purification of specific beta1-G-globulin]." in: Voprosy medit͡sinskoĭ khimii, Vol. 24, Issue 2, pp. 240-4, 1978