Pregnancy Specific beta-1-Glycoprotein 5 (PSG5) antibody

Details for Product No. ABIN108731
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Antigen
Synonyms FL-NCA-3, PSG
Reactivity
Human
(5), (1), (1), (1)
Host
Mouse (Murine)
(6), (1)
Clonality (Clone)
Monoclonal ()
Application
Flow Cytometry (FACS), Immunohistochemistry (IHC)
(7), (1)
Pubmed 7 references available
Quantity 100 µL
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Catalog No. ABIN108731
450.12 $
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Immunogen immunisation with extracted protein of human PSG
Clone BAP3
Isotype IgG1
Specificity BAC2 recognizes exclusively CEACAM7 transiently expressed on the cell surface of transfected BOSC23 cells. BAC2 can be used to distinguish CEACAM7 from all other CEACAM and probably all pregnancy-specific glycoprotein molecules, namely CEACAM1 (B
Purification Protein G
Alternative Name PSG
Background BAP3 reacts with human pregnancy-specific glycoproteins (PSG), a group of closely related secreted glycoproteins which are highly expressed in placental syncytiotrophoblast cells of fetal origin. PSG are commonly expressed in tumors of trophoblast origin (hydatidiform mole, choriocarcinoma). They represent the most abundant fetal protein in the maternal blood at term. The eleven human PSG genes (PSG1-PSG11) form together with the carcinoembryonic antigen (CEA)-related cell adhesion molecule (CEACAM) genes the CEACAM gene family. PSG stimulates secretion of TH2-type cytokines from monocytes. CD9 was shown to represent the monocyte receptor for murine PSG17. PSG are thought to modulate the maternal immune system during pregnancy thus protecting the semiallotypic fetus from rejection.
UniProt P11464
Application Notes Flow cytometry: 1.2 µg/10^6 cells
For each application a titration should be performed to determine the optimal concentration.
Comment

Synonyms: pregnancy-specific glycoprotein 1, CD66f

Restrictions For Research Use only
Format Liquid
Concentration 1 mg/mL
Buffer PBS, pH 7.2
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C
Storage Comment short term: 2 °C - 8 °C, long term: -20 °C
Supplier Images
anti-Pregnancy Specific beta-1-Glycoprotein 5 (PSG5) antibody Detection of recombinant transmembrane-anchored PSG1 fusion protein on HeLa transfectants by BAP3. A HeLa transfectant expressing a recombinant, transmembrane-anchored form of PSG1 (red curve) and the corresponding parental cell line (green curve) were r
Background publications Thomas, Zhu, Schnaar et al.: "Carcinoembryonic antigen and CD44 variant isoforms cooperate to mediate colon carcinoma cell adhesion to E- and L-selectin in shear flow." in: The Journal of biological chemistry, Vol. 283, Issue 23, pp. 15647-55, 2008 (PubMed).

General Sokolov, Kozliaeva, Mesniankina et al.: "[Isolation and purification of specific beta1-G-globulin]." in: Voprosy medit͡sinskoĭ khimii, Vol. 24, Issue 2, pp. 240-4, 1978 (PubMed).

Zhou, Baranov, Zimmermann et al.: "Highly specific monoclonal antibody demonstrates that pregnancy-specific glycoprotein (PSG) is limited to syncytiotrophoblast in human early and term placenta." in: Placenta, Vol. 18, Issue 7, pp. 491-501, 1997 (PubMed).

Hammarström: "The carcinoembryonic antigen (CEA) family: structures, suggested functions and expression in normal and malignant tissues." in: Seminars in cancer biology, Vol. 9, Issue 2, pp. 67-81, 1999 (PubMed).

Snyder, Wessner, Wessells et al.: "Pregnancy-specific glycoproteins function as immunomodulators by inducing secretion of IL-10, IL-6 and TGF-beta1 by human monocytes." in: American journal of reproductive immunology (New York, N.Y. : 1989), Vol. 45, Issue 4, pp. 205-16, 2001 (PubMed).

Beauchemin, Draber, Dveksler et al.: "Redefined nomenclature for members of the carcinoembryonic antigen family." in: Experimental cell research, Vol. 252, Issue 2, pp. 243-9, 2001 (PubMed).

Waterhouse, Ha, Dveksler: "Murine CD9 is the receptor for pregnancy-specific glycoprotein 17." in: The Journal of experimental medicine, Vol. 195, Issue 2, pp. 277-82, 2002 (PubMed).

Validation Images
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