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Details for Product No. ABIN1098143

ATP Citrate Lyase (ACLY) (AA 306-502) antibody

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Antigen
Synonyms
ACL, ATPCL, CLATP, Clatp, AW538652, A730098H14Rik, acly, cb722, zgc:92008, ACLY, DDBDRAFT_0205389, DDBDRAFT_0235360, DDB_0205389, DDB_0235360, BcDNA:LD21334, CG8322, DmATPCL, Dmel\\CG8322, anon-WO0140 ... show more
Epitope
»Alternatives AA 306-502
Reactivity
»Alternatives Human, Mouse (Murine), Monkey, Rat (Rattus)
Host
»Alternatives Mouse
Clonality (Clone) Monoclonal ()
Conjugate
»Alternatives Un-conjugated
Application
»Alternatives ELISA, Western Blotting (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Fluorescence Microscopy (FM)
Pubmed 2 references available
Catalog no. ABIN1098143
Quantity 0.1 mg
Price
396.00 $   Plus shipping costs $45.00
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Availability Will be delivered in 3 to 4 Business Days
Immunogen Purified recombinant fragment of human ACLY (AA 306-502 ) expressed in E. coli.
Clone 5F8D11
Isotype IgG1
Purification Purified
Alternative Name ACLY
Background Synonyms:
ACL, ATPCL, CLATP
ATP citrate lyase is the primary enzyme responsible for the synthesis of cytosolic acetyl-CoA in many tissues. The enzyme is a tetramer (relative molecular weight approximately 440,000) of apparently identical subunits. It catalyzes the formation of acetyl-CoA and oxaloacηte from citrate and CoA with a concomitant hydrolysis of ATP to ADP and phosphate. The product, acetyl-CoA, serves several important biosynthetic pathways, including lipogenesis and cholesterogenesis. In nervous tissue, ATP citrate-lyase may be involved in the biosynthesis of acetylcholine. Two transcript variants encoding distinct isoforms have been identified for this gene. ,,,
Molecular Weight 125 kDa
Gene ID 47
Application Notes Recommended Dilution:
ELISA: 1/10000, WB: 1/500 - 1/2000, IHC: 1/200 - 1/1000, ICC: 1/50, FCM: 1/200 - 1/400
Not yet tested in other applications.
Determining optimal working dilutions by titration test.
Restrictions For Research Use only
Buffer PBS with 0.05 % sodium azide and 0.5 % protein stabilizer
Preservative Sodium azide
Storage 4 °C/-20 °C
Storage Comment Store at 4 °C or at -20 °C for long term.
Product cited in: Beckner, Fellows-Mayle, Zhang et al.: "Identification of ATP citrate lyase as a positive regulator of glycolytic function in glioblastomas." in: International journal of cancer. Journal international du cancer, Vol. 126, Issue 10, pp. 2282-95, 2010 (PubMed).

Chu, Lin, Hendel et al.: "ATP-citrate lyase reduction mediates palmitate-induced apoptosis in pancreatic beta cells." in: The Journal of biological chemistry, Vol. 285, Issue 42, pp. 32606-15, 2010 (PubMed).

Alternatives for antigen "ATP Citrate Lyase (ACLY)", type "Antibodies"
Hosts (61), (8)
Reactivities (63), (44), (43), (27), (27), (26), (24), (3), (1), (1), (1)
Applications (50), (29), (20), (11), (8), (7), (6), (4), (4), (3)
Conjugates (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2)
Epitopes (17), (6), (4), (2), (2), (2), (2), (1), (1), (1), (1)
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