Serotonin Receptor 1A antibody (AA 249-262)

Catalog No. ABIN1099742

Product Details anti-Serotonin Receptor 1A Antibody

Target: Serotonin Receptor 1A (HTR1A)

Binding Specificity: AA 249-262

Reactivity: Human

Host: Goat

Clonality: Polyclonal

Conjugate: This Serotonin Receptor 1A antibody is un-conjugated

Application: ELISA

Specificity: Human 5HT1A Receptor.

Predicted Reactivity: Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Marmoset (100%) Monkey (93%) Panda (86%).

Purification: Immunoaffinity purified

Immunogen: Synthetic peptide C-QPKKSVNGESGSRN from an internal region of human 5HT1A Receptor (NP_000515.2). Percent identity by BLAST analysis: Human, Chimpanzee, Gorilla, Orangutan, Gibbon, Marmoset (100%), Monkey (93%), Panda (86%).

Type of Immunogen: Synthetic peptide

Application Details

Application Notes: Approved: Peptide-ELISA (1:16000)

Usage: Peptide ELISA: antibody detection limit dilution 1:16000. Western blot: Preliminary experiments gave bands at approx 37kD and 35kD in Human Brain (Hippocampus, Substantia nigra) lysates after 0.1 μg/mL antibody staining. Please note that currently we cannot find an explanation in the literature for the bands we observe given the calculated size of 46.1kD according to NP_000515.2. Both detected bands were successfully blocked by incubation with the immunizing peptide (and BLAST results with the immunizing peptide sequence did not identify any other proteins to explain the additional bands).

Comment:

Target Species of Antibody: Human

Restrictions: For Research Use only

Handling

Format: Liquid

Concentration: Lot specific

Buffer: Tris-buffered saline,  pH 7.3, 0.5 % BSA, 0.02 % sodium azide

Preservative: Sodium azide

Precaution of Use: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handling Advice: Minimize freezing and thawing.

Storage: -20 °C

Storage Comment: Store at -20°C. Avoid freeze-thaw cycles.

Target Details for Serotonin Receptor 1A

Target: Serotonin Receptor 1A (HTR1A)

Alternative Name: HTR1A / 5-HT1A Receptor (HTR1A Products)

Synonyms: 5-HT-dro2A antibody, 5-HT1ADro antibody, 5-HT[1A]Dro antibody, 5-HT[[1ADro]] antibody, 5-HT[[1A]] antibody, 5-HT[[1A]]DRO antibody, 5HT-R2A antibody, 5HT-dro2A antibody, 5HT-drp[[2A]] antibody, 5HT1A antibody, 5HT[[1ADro]] antibody, 5htdro2a antibody, CG16720 antibody, DRO2A antibody, Dm5HTdro2A antibody, Dmel\\CG16720 antibody, d5-HT1A antibody, 5htr1a antibody, htr1a antibody, HTR1A antibody, Htr1a antibody, 5-Ht1a antibody, Gpcr18 antibody, 5-HT-1A antibody, 5-HT1A antibody, 5HT1a antibody, ADRB2RL1 antibody, ADRBRL1 antibody, G-21 antibody, PFMCD antibody, RAT5HT1A antibody, 5ht1a antibody, adrb2rl1 antibody, adrbrl1 antibody, htr1a-A antibody, 5-hydroxytryptamine (serotonin) receptor 1A antibody, 5-hydroxytryptamine receptor 1A antibody, 5-hydroxytryptamine (serotonin) receptor 1A a antibody, 5-hydroxytryptamine (serotonin) receptor 1A, G protein-coupled L homeolog antibody, 5-HT1A antibody, HTR1A antibody, htr1aa antibody, Htr1a antibody, htr1a.L antibody

Background: Name/Gene ID: HTR1A
Subfamily: Serotonin
Family: GPCR

Synonyms: HTR1A, 5-HT-1A, 5HT1a, 5-HT1a receptor, 5HT1ar, 5HT1A receptor, 5-HT1A, ADRBRL1, ADRB2RL1, PFMCD, Serotonin 5-HT-1a receptor, Serotonin type 1a receptor, Serotonergic type 1A receptor, G-21, Serotonin 1a receptor, Serotonin receptor 1A

Gene ID: 3350

NCBI Accession: NP_000515

UniProt: P08908

Pathways: JAK-STAT Signaling, Synaptic Membrane, Feeding Behaviour