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ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2) antibody

Details for Product No. ABIN1105167, Supplier: Login to see
Antigen
  • ABC30
  • CMOAT
  • DJS
  • MRP2
  • cMRP
  • AI173996
  • Abc30
  • Cmoat
  • Mrp2
Reactivity
Human, Mouse (Murine), Rat (Rattus)
53
6
2
Host
Mouse
29
27
Clonality (Clone)
Monoclonal ()
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
51
22
21
16
13
11
9
4
2
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Immunogen A fusion protein of the bacterial maltose binding protein and Rat Mrp2, containing the 202-amino acid COOH terminal end of the transporter protein.
Clone M2III-5
Isotype IgG2b
Specificity This Monoclonal antibody clone M2III-5 reacts with an internal epitope of MRP2. The Mab detects Rat, Mouse and Human MRP2. M2III-5 does not cross-react with the Human MDR1 P-gp, MRP1, MRP3 orMRP5 gene products.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse and Rat.
Purification Supernatant
Alternative Name ABCC2 / CMOAT / MRP2 (ABCC2 Antibody Abstract)
Background MRP2 is a 190-200 kD transmembrane protein earlier known as the canalicular multi-organic anion transporter cMOAT, absent in patients with the Dubin-Johnson syndrome, an autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. MRP2 is a member of the MRP family of multidrug resistance related proteins, and MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines.Synonyms: ATP-binding cassette sub-family C member 2, CMOAT1, CMRP, Canalicular multidrug resistance protein, Canalicular multispecific organic anion transporter 1, Multidrug resistance-associated protein 2
Gene ID 1244
NCBI Accession NP_000383
UniProt Q92887
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL IgG
Buffer 0.09 % Sodium Azide 0.9 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Peng, Yanagida, Chen et al.: "Ellipsoidal TiO2 hierarchitectures with enhanced photovoltaic performance." in: Chemistry (Weinheim an der Bergstrasse, Germany), Vol. 18, Issue 17, pp. 5269-74, 2012 (PubMed).

Scheffer, Kool, Heijn et al.: "Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies." in: Cancer research, Vol. 60, Issue 18, pp. 5269-77, 2000 (PubMed).

Kool, de Haas, Scheffer et al.: "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines." in: Cancer research, Vol. 57, Issue 16, pp. 3537-47, 1997 (PubMed).

Paulusma, Bosma, Zaman et al.: "Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene." in: Science (New York, N.Y.), Vol. 271, Issue 5252, pp. 1126-8, 1996 (PubMed).