ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2) antibody

Details for Product No. ABIN1105167
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Antigen
Synonyms ABC30, CMOAT, DJS, MRP2, cMRP, AI173996, Abc30, Cmoat, Mrp2
Reactivity
Human, Mouse (Murine), Rat (Rattus)
(49), (6), (2)
Host
Mouse
(30), (23)
Clonality (Clone)
Monoclonal ()
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(51), (23), (22), (16), (15), (14), (10), (3), (2)
Pubmed 4 references available
Quantity 1 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN1105167
588.50 $
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Immunogen A fusion protein of the bacterial maltose binding protein and Rat Mrp2, containing the 202-amino acid COOH terminal end of the transporter protein.
Clone M2III-5
Isotype IgG2b
Specificity This Monoclonal antibody clone M2III-5 reacts with an internal epitope of MRP2. The Mab detects Rat, Mouse and Human MRP2. M2III-5 does not cross-react with the Human MDR1 P-gp, MRP1, MRP3 orMRP5 gene products.
Purification Supernatant
Alternative Name ABCC2 / CMOAT / MRP2
Background MRP2 is a 190-200 kD transmembrane protein earlier known as the canalicular multi- organic anion transporter cMOAT, absent in patients with the Dubin-Johnson syndrome, an autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. MRP2 is a member of the MRP family of multidrug resistance related proteins, and MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines.
Alternate names: ATP-binding cassette sub-family C member 2, CMOAT1, CMRP, Canalicular multidrug resistance protein, Canalicular multispecific organic anion transporter 1, Multidrug resistance-associated protein 2
Gene ID 1244
NCBI Accession NP_000383
UniProt Q92887
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL IgG
Buffer 0.09% Sodium Azide 0.7% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Paulusma, Bosma, Zaman et al.: "Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene." in: Science (New York, N.Y.), Vol. 271, Issue 5252, pp. 1126-8, 1996 (PubMed).

Kool, de Haas, Scheffer et al.: "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines." in: Cancer research, Vol. 57, Issue 16, pp. 3537-47, 1997 (PubMed).

Scheffer, Kool, Heijn et al.: "Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies." in: Cancer research, Vol. 60, Issue 18, pp. 5269-77, 2000 (PubMed).

Peng, Yanagida, Chen et al.: "Ellipsoidal TiO2 hierarchitectures with enhanced photovoltaic performance." in: Chemistry (Weinheim an der Bergstrasse, Germany), Vol. 18, Issue 17, pp. 5269-74, 2012 (PubMed).

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