You are viewing an incomplete version of our website. Please click to reload the website as full version.

ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2) antibody

Details for Product No. ABIN1105167, Supplier: Log in to see
  • ABC30
  • DJS
  • MRP2
  • cMRP
  • AI173996
  • Abc30
  • Cmoat
  • Mrp2
  • ATP-binding cassette, sub-family C (CFTR/MRP), member 2
  • ATP-binding cassette, subfamily C (CFTR/MRP), member 2
  • ABCC2
  • Abcc2
Human, Mouse (Murine), Rat (Rattus)
Clonality (Clone)
Monoclonal ()
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
Log in to see
Supplier Product No.
Log in to see

Get this product for free

It's quick and easy to submit your validation proposal. I want to validate this product

Learn more

Immunogen A fusion protein of the bacterial maltose binding protein and Rat Mrp2, containing the 202-amino acid COOH terminal end of the transporter protein.
Clone M2III-5
Isotype IgG2b
Specificity This Monoclonal antibody clone M2III-5 reacts with an internal epitope of MRP2. The Mab detects Rat, Mouse and Human MRP2. M2III-5 does not cross-react with the Human MDR1 P-gp, MRP1, MRP3 orMRP5 gene products.
Cross-Reactivity (Details) Species reactivity (tested):Human, Mouse and Rat.
Purification Supernatant
Alternative Name ABCC2 / CMOAT / MRP2 (ABCC2 Antibody Abstract)
Background MRP2 is a 190-200 kD transmembrane protein earlier known as the canalicular multi-organic anion transporter cMOAT, absent in patients with the Dubin-Johnson syndrome, an autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. MRP2 is a member of the MRP family of multidrug resistance related proteins, and MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines.Synonyms: ATP-binding cassette sub-family C member 2, CMOAT1, CMRP, Canalicular multidrug resistance protein, Canalicular multispecific organic anion transporter 1, Multidrug resistance-associated protein 2
Gene ID 1244
NCBI Accession NP_000383
UniProt Q92887
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg/mL IgG
Buffer 0.09 % Sodium Azide 0.9 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Peng, Yanagida, Chen, Han: "Ellipsoidal TiO2 hierarchitectures with enhanced photovoltaic performance." in: Chemistry (Weinheim an der Bergstrasse, Germany), Vol. 18, Issue 17, pp. 5269-74, 2012 (PubMed).

Scheffer, Kool, Heijn, de Haas, Pijnenborg, Wijnholds, van Helvoort, de Jong, Hooijberg, Mol, van der Linden, de Vree, van der Valk, Elferink, Borst, Scheper: "Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies." in: Cancer research, Vol. 60, Issue 18, pp. 5269-77, 2000 (PubMed).

Kool, de Haas, Scheffer, Scheper, van Eijk, Juijn, Baas, Borst: "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines." in: Cancer research, Vol. 57, Issue 16, pp. 3537-47, 1997 (PubMed).

Paulusma, Bosma, Zaman, Bakker, Otter, Scheffer, Scheper, Borst, Oude Elferink: "Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene." in: Science (New York, N.Y.), Vol. 271, Issue 5252, pp. 1126-8, 1996 (PubMed).