ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 2 (ABCC2) (AA 215-310) antibody

Details for Product No. ABIN1105170
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Antigen
Synonyms ABC30, CMOAT, DJS, MRP2, cMRP, AI173996, Abc30, Cmoat, Mrp2
Epitope
AA 215-310
(9), (4), (3), (2), (2), (1), (1), (1), (1), (1), (1)
Reactivity
Human
(49), (8), (3)
Host
Mouse
(30), (23)
Clonality (Clone)
Monoclonal ()
Application
Immunocytochemistry (ICC), Immunofluorescence (IF), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
(51), (23), (22), (17), (15), (14), (10), (3), (2)
Pubmed 2 references available
Quantity 1 mL
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Catalog No. ABIN1105170
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Immunogen Bacterial fusion protein of cMOAB/MRP2, containing amino acids 215-310 of the protein.
Clone M2I-4
Isotype IgG1
Specificity This Monoclonal antibody M2I-4 reacts with an internal epitope of cMOAT/MRP2, a 170-180 kD transmembrane protein. It did not cross react with the Human MDR1, MRP1, MRP3 and MRP5 gene products.
Purification Supernatant
Alternative Name ABCC2 / CMOAT / MRP2
Background The two members of the large family of ABC transporters known to confer multidrug resistance in human cancer cells are the MDR1 P-glycoprotein and the multidrug-resistance protein MRP1. MRP1 is an integral membrane protein that contains an MDR-like core, an N- terminal membrane-bound region and a cytoplasmic linker, and it is expressed in various cerebral cells, as well as in lung, testis and peripheral blood. The MRP gene family also includes MRP2, which is alternatively designated cMOAT (for canalicular multispecific organic anion transporter) and MRP3, which are both conjugate export pumps expressed predominantly in hepatocytes. MRP2 localizes exclusively to the apical membrane and is constitutively expressed at a high level in normal liver cells. Conversely, MRP3 localizes to the asolateral membrane where it also mediates the transport of the organic anion S-(2,4-dinitrophenyl-) glutathione toward the basolateral side of the membrane. MRP3 is normally expressed at comparatively lower levels than MRP2 and increases only when secretion across the apical membrane by MRP2 is impaired. MRP6 protein is highly expressed in liver and kidney, whereas MRP4 and MRP5 are detected in various tissues yet at much lower levels of expression. cMOAT/MRP2 is a 170-180 kD transmembrane protein known as the canalicular multi- organic anion transporter, absent in patients with the Dubin-Johnson syndrome, an autosomal recessive liver disorder characterized by chronic conjugated hyperbilirubinemia. cMOAT/MRP2 is closely related to the multidrug resistance related protein MRP, and cMOAT/MRP2 overexpression has been observed in a subset of cisplatin resistant cell lines.
Alternate names: ATP-binding cassette sub-family C member 2, CMOAT1, CMRP, Canalicular multidrug resistance protein, Canalicular multispecific organic anion transporter 1, Multidrug resistance-associated protein 2
Gene ID 1244
NCBI Accession NP_000383
UniProt Q92887
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg Ig /ml
Buffer 0.09% Sodium Azide 0.7% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8°C for one month or (in aliquots) at -20°C for longer.
Expiry Date 12 months
Background publications Paulusma, Bosma, Zaman et al.: "Congenital jaundice in rats with a mutation in a multidrug resistance-associated protein gene." in: Science (New York, N.Y.), Vol. 271, Issue 5252, pp. 1126-8, 1996 (PubMed).

Kool, de Haas, Scheffer et al.: "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines." in: Cancer research, Vol. 57, Issue 16, pp. 3537-47, 1997 (PubMed).

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