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ABCC3 antibody (ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 3) (AA 830-949)

Details for Product anti-ABCC3 Antibody No. ABIN1105171, Supplier: Log in to see
Antigen
  • 1700019L09Rik
  • ABC31
  • cMOAT2
  • EST90757
  • MLP2
  • Mlp2
  • MOAT-D
  • Mrp3
  • MRP3
Epitope
AA 830-949
16
15
12
3
2
2
1
1
1
Reactivity
Human
70
17
15
1
1
Host
Mouse
51
10
10
Clonality (Clone)
Monoclonal ()
Conjugate
This ABCC3 antibody is un-conjugated
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
53
34
20
18
11
10
6
6
5
2
1
Supplier
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Supplier Product No.
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Immunogen Bacterial fusion protein of MRP3, containing amino acids 830-949 of the protein.
Clone M3II-21
Isotype IgG2b
Specificity This Monoclonal antibody M3II-21 reacts with an internal epitope of MRP3, a 190-200 kDa transmembrane protein that is closely related to the multidrug resistance protein MRP1. It does not cross-react with the Human MDR1, MRP1, MRP2 or MRP5 gene products.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Supernatant
Alternative Name ABCC3 / CMOAT2 / MRP3 (ABCC3 Antibody Abstract)
Background Human multidrug-resistance protein (MRP) gene family is composed of multiple members including MRP 1, MRP 2 or cMOAT and four other homologous genes called MRP 3, MRP 4, MRP 5 and MRP 6. Canalicular Multi Organic Anion Transporter 2 / Multidrug Resistance Associated Protein 3 (cMOAT 2 / MRP 3) has a molecular weight of 190-200 kD. MRP3 is closest to MRP1 with 58 % amino acid identity. MRP 3 has been shown to be mainly expressed in the liver, colon, intestine, adrenal gland and, to a lower extent, in several other tissues.Synonyms: Canalicular multispecific organic anion transporter 2, MLP2, Multidrug resistance-associated protein 3
Gene ID 8714
NCBI Accession NP_001137542
UniProt O15438
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg Ig /ml
Buffer 0.09 % Sodium Azide 0.9 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Kool, van der Linden, de Haas, Scheffer, de Vree, Smith, Jansen, Peters, Ponne, Scheper, Elferink, Baas, Borst: "MRP3, an organic anion transporter able to transport anti-cancer drugs." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 96, Issue 12, pp. 6914-9, 1999

Kool, de Haas, Scheffer, Scheper, van Eijk, Juijn, Baas, Borst: "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines." in: Cancer research, Vol. 57, Issue 16, pp. 3537-47, 1997