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ATP-Binding Cassette, Sub-Family C (CFTR/MRP), Member 5 (ABCC5) (AA 722-910) antibody

Details for Product No. ABIN1105176, Supplier: Log in to see
Antigen
  • ABC33
  • EST277145
  • MOAT-C
  • MOATC
  • MRP5
  • SMRP
  • pABC11
  • 2900011L11Rik
  • AI132311
  • Abcc5a
  • Abcc5b
  • Mrp5
  • EG636260
  • Gm7175
Epitope
AA 722-910
18
14
10
3
3
2
2
1
1
Reactivity
Human
83
24
23
6
6
3
2
2
1
Host
Rat
40
19
13
12
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunofluorescence (IF), Western Blotting (WB)
70
34
25
11
11
10
7
6
6
2
1
Supplier
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Immunogen Bacterial fusion protein of MRP5, containing amino acids 722-910 of the protein.
Clone M5II-54
Isotype IgG2a
Specificity This Monoclonal antibody M5II-54 reacts with an internal epitope of MRP5, a 190-200 kDa transmembrane protein that is closely related to the multidrug resistance protein MRP. It does not cross-react with the Human MDR1, MRP1, MRP2 or MRP3 gene products.
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Supernatant
Alternative Name ABCC5 / MRP5 (ABCC5 Antibody Abstract)
Background MRP5 (190-200 kDa) is closely related to MRP4, both lacking the first five membrane spanning regions. MRP5 is a GS-X multi specific organic anion pump (nucleotide analogs). MRP5 may transport DNP-GS and may be inhibited by certain inhibitors of organic anion transport (sulfinpyrazone). MRP5 may also transport organic anions with the anionic moiety of phosphate/phosphonate group, a function which provides the ability to resist against anti cancer drugs 6-MP and thioguanine as well as the anti-HIV drug PMEA.Synonyms: ATP-binding cassette sub-family C member 5, MOAT-C, Multi-specific organic anion transporter C, Multidrug resistance-associated protein 5, SMRP, pABC11
Gene ID 10057
NCBI Accession NP_005679
UniProt O15440
Pathways
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Concentration 0.25 mg IgG /ml
Buffer 0.09 % Sodium Azide 0.9 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Scheffer, Kool, Heijn et al.: "Specific detection of multidrug resistance proteins MRP1, MRP2, MRP3, MRP5, and MDR3 P-glycoprotein with a panel of monoclonal antibodies." in: Cancer research, Vol. 60, Issue 18, pp. 5269-77, 2000 (PubMed).

Kool, de Haas, Scheffer et al.: "Analysis of expression of cMOAT (MRP2), MRP3, MRP4, and MRP5, homologues of the multidrug resistance-associated protein gene (MRP1), in human cancer cell lines." in: Cancer research, Vol. 57, Issue 16, pp. 3537-47, 1997 (PubMed).