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ACTA2 / Aortic Smooth Muscle Actin antibody

Details for Product No. ABIN1105231, Supplier: Log in to see
Antigen
Reactivity
Human, Monkey, Mouse (Murine), Rat (Rattus)
15
10
10
8
8
7
4
1
1
1
Host
Mouse
8
6
1
Clonality (Clone)
Monoclonal ()
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
15
7
5
4
2
Supplier
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Clone 1H8
Isotype IgG1
Specificity This antibody recognizes Human, Monkey, Rat, Mouse ACTA2. Other species not tested.
Purification Ascites
Background The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified.Synonyms: ACTSA, ACTVS, Alpha-actin-2, Cell growth-inhibiting gene 46 protein
Molecular Weight 42 kDa
Gene ID 59
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer 0.03 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Immunofluorescence (IF) image for anti-ACTA2 / Aortic Smooth Muscle Actin antibody (ABIN1105231) anti-ACTA2 / Aortic Smooth Muscle Actin antibody
Western Blotting (WB) image for anti-ACTA2 / Aortic Smooth Muscle Actin antibody (ABIN1105231) anti-ACTA2 / Aortic Smooth Muscle Actin antibody (Image 2)
Flow Cytometry (FACS) image for anti-ACTA2 / Aortic Smooth Muscle Actin antibody (ABIN1105231) anti-ACTA2 / Aortic Smooth Muscle Actin antibody (Image 3)
ELISA image for anti-ACTA2 / Aortic Smooth Muscle Actin antibody (ABIN1105231) anti-ACTA2 / Aortic Smooth Muscle Actin antibody (Image 4)
Background publications Guo, Pannu, Tran-Fadulu et al.: "Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections." in: Nature genetics, Vol. 39, Issue 12, pp. 1488-93, 2007 (PubMed).

Salas, Bartoli, Deville et al.: "Ezrin and alpha-smooth muscle actin are immunohistochemical prognostic markers in conventional osteosarcomas." in: Virchows Archiv : an international journal of pathology, Vol. 451, Issue 6, pp. 999-1007, 2007 (PubMed).