Smooth Muscle Actin antibody (Actin, alpha 2, Smooth Muscle, Aorta)

Details for Product anti-ACTA2 Antibody No. ABIN1105231, Supplier: Log in to see
Antigen
  • ASMA
  • SMactin
  • a-sma
  • aat6
  • actsa
  • mymy5
  • sm-actin
  • ACTA2
  • actc1
  • ACT-4
  • AAT6
  • ACTSA
  • MYMY5
  • 0610041G09Rik
  • Actvs
  • SMalphaA
  • a-SMA
  • alphaSMA
  • wu:fb63d03
  • asma
  • actin, alpha 2, smooth muscle, aorta
  • acta2
  • ACTA2
  • Acta2
Alternatives
anti-Human Smooth Muscle Actin antibody for Immunohistochemistry (Frozen Sections)
Reactivity
Human, Monkey, Mouse (Murine), Rat (Rattus)
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141
132
64
51
44
34
21
10
10
8
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5
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4
2
2
2
2
2
1
Host
Mouse
165
105
15
Clonality (Clone)
Monoclonal ()
Conjugate
This Smooth Muscle Actin antibody is un-conjugated
9
5
4
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3
3
3
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
172
117
97
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53
48
20
17
13
7
4
3
3
3
1
1
1
1
1
Options
Supplier
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Supplier Product No.
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Clone 1H8
Isotype IgG1
Specificity This antibody recognizes Human, Monkey, Rat, Mouse ACTA2. Other species not tested.
Purification Ascites
Background The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified.Synonyms: ACTSA, ACTVS, Alpha-actin-2, Cell growth-inhibiting gene 46 protein
Molecular Weight 42 kDa
Gene ID 59
Pathways Myometrial Relaxation and Contraction, Skeletal Muscle Fiber Development
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer 0.03 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Immunofluorescence (IF) image for anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) antibody (ABIN1105231) anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) antibody
Western Blotting (WB) image for anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) antibody (ABIN1105231) anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) antibody (Image 2)
Flow Cytometry (FACS) image for anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) antibody (ABIN1105231) anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) antibody (Image 3)
ELISA image for anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) antibody (ABIN1105231) anti-Actin, alpha 2, Smooth Muscle, Aorta (ACTA2) antibody (Image 4)
Background publications Guo, Pannu, Tran-Fadulu, Papke, Yu, Avidan, Bourgeois, Estrera, Safi, Sparks, Amor, Ades, McConnell, Willoughby, Abuelo, Willing, Lewis, Kim, Scherer, Tung, Ahn, Buja, Raman, Shete, Milewicz: "Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections." in: Nature genetics, Vol. 39, Issue 12, pp. 1488-93, 2007 (PubMed).

Salas, Bartoli, Deville, Gaudart, Fina, Calisti, Bollini, Curvale, Gentet, Duffaud, Figarella-Branger, Bouvier: "Ezrin and alpha-smooth muscle actin are immunohistochemical prognostic markers in conventional osteosarcomas." in: Virchows Archiv : an international journal of pathology, Vol. 451, Issue 6, pp. 999-1007, 2007 (PubMed).

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