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ACTA2 / Aortic Smooth Muscle Actin antibody

Details for Product No. ABIN1105232, Supplier: Log in to see
Antigen
Reactivity
Human, Monkey
13
10
10
8
8
7
4
1
Host
Mouse
8
5
Clonality (Clone)
Monoclonal ()
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
12
6
5
3
2
1
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Clone 4F4
Isotype IgG1
Specificity Recognizes ACTA2
Cross-Reactivity (Details) Species reactivity (tested):Human, Monkey.
Purification Ascites
Background The protein encoded by this gene belongs to the actin family of proteins, which are highly conserved proteins that play a role in cell motility, structure and integrity. Alpha, beta and gamma actin isoforms have been identified, with alpha actins being a major constituent of the contractile apparatus, while beta and gamma actins are involved in the regulation of cell motility. This actin is an alpha actin that is found in skeletal muscle. Defects in this gene cause aortic aneurysm familial thoracic type 6. Multiple alternatively spliced variants, encoding the same protein, have been identified.Synonyms: ACTSA, ACTVS, Alpha-actin-2, Cell growth-inhibiting gene 46 protein
Molecular Weight 42 kDa
Gene ID 59
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
ELISA image for anti-ACTA2 / Aortic Smooth Muscle Actin antibody (ABIN1105232) anti-ACTA2 / Aortic Smooth Muscle Actin antibody
Western Blotting (WB) image for anti-ACTA2 / Aortic Smooth Muscle Actin antibody (ABIN1105232) anti-ACTA2 / Aortic Smooth Muscle Actin antibody (Image 2)
Immunohistochemistry (IHC) image for anti-ACTA2 / Aortic Smooth Muscle Actin antibody (ABIN1105232) anti-ACTA2 / Aortic Smooth Muscle Actin antibody (Image 3)
Immunohistochemistry (IHC) image for anti-ACTA2 / Aortic Smooth Muscle Actin antibody (ABIN1105232) anti-ACTA2 / Aortic Smooth Muscle Actin antibody (Image 4)
Background publications Guo, Pannu, Tran-Fadulu, Papke, Yu, Avidan, Bourgeois, Estrera, Safi, Sparks, Amor, Ades, McConnell, Willoughby, Abuelo, Willing, Lewis, Kim, Scherer, Tung, Ahn, Buja, Raman, Shete, Milewicz: "Mutations in smooth muscle alpha-actin (ACTA2) lead to thoracic aortic aneurysms and dissections." in: Nature genetics, Vol. 39, Issue 12, pp. 1488-93, 2007 (PubMed).

Salas, Bartoli, Deville, Gaudart, Fina, Calisti, Bollini, Curvale, Gentet, Duffaud, Figarella-Branger, Bouvier: "Ezrin and alpha-smooth muscle actin are immunohistochemical prognostic markers in conventional osteosarcomas." in: Virchows Archiv : an international journal of pathology, Vol. 451, Issue 6, pp. 999-1007, 2007 (PubMed).