Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody

Details for Product No. ABIN1105244
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Antigen
Synonyms 2310079H06Rik, A130023A14, AA474864, AV021921, D030051N19Rik, mKIAA1736, Nyw1, DCAF3, WDR94
Epitope
N-Term
(20), (12), (2), (2), (1), (1), (1), (1)
Reactivity
Mouse (Murine)
(56), (47), (31), (13), (12), (1)
Host
Rabbit
(62), (1)
Clonality
Polyclonal
Conjugate
Un-conjugated
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Western Blotting (WB)
(54), (30), (28), (14), (10), (7), (3), (3), (1), (1)
Pubmed 3 references available
Quantity 0.2 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1105244
555.50 $
Plus shipping costs $45.00

Order hotline:

  • +1 404 474 4654
  • +1 888 205 9894 (TF)
Immunogen Synthetic peptide derived from N-term domain of the mouse Ambra 1 protein.
Specificity This antibody reacts with Mouse 120 kDa Ambra1 protein.
Cross-Reactivity (Details) Species reactivity (expected):Human and Rat.
Species reactivity (tested):Mouse.
Purification Serum
Alternative Name AMBRA1
Background Synonyms: Activating molecule in BECN1-regulated autophagy protein 1, KIAA1736
Gene ID 228361
NCBI Accession NP_060219
Research Area Cancer, Autophagy, Neurogenesis
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Reconstitution Restore in distilled water.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Background publications Di Bartolomeo, Corazzari, Nazio et al.: "The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy." in: The Journal of cell biology, Vol. 191, Issue 1, pp. 155-68, 2010 (PubMed).

Armstrong, Corazzari, Martin et al.: "Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 8, pp. 2216-26, 2011 (PubMed).

Pagliarini, Wirawan, Romagnoli et al.: "Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response." in: Cell death and differentiation, Vol. 19, Issue 9, pp. 1495-504, 2012 (PubMed).

Validation Images
Did you look for something else?
back to top