Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody

Details for Product No. ABIN1105244
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Synonyms 2310079H06Rik, A130023A14, AA474864, AV021921, D030051N19Rik, mKIAA1736, Nyw1, DCAF3, WDR94
(26), (19), (12), (4), (1), (1), (1), (1), (1), (1)
Mouse (Murine)
(77), (50), (34), (1), (1)
(1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA), Western Blotting (WB)
(66), (40), (32), (19), (10), (8), (6), (4), (3), (1)
Pubmed 3 references available
Quantity 0.2 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Immunogen Synthetic peptide derived from N-term domain of the mouse Ambra 1 protein.
Specificity This antibody reacts with Mouse 120 kDa Ambra1 protein.
Cross-Reactivity (Details) Species reactivity (expected):Human and Rat.
Species reactivity (tested):Mouse.
Purification Serum
Alternative Name AMBRA1 (AMBRA1 Antibody Abstract)
Background Synonyms: Activating molecule in BECN1-regulated autophagy protein 1, KIAA1736
Gene ID 228361
NCBI Accession NP_060219
Research Area Cancer, Autophagy, Neurogenesis
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Reconstitution Restore in distilled water.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Frozen Sections) (IHC (fro)) image for anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody (ABIN1105244) Activating molecule in BECN1-regulated autophagy protein 1 (Ambra1) antibody
Immunofluorescence (IF) image for anti-Autophagy/beclin-1 Regulator 1 (AMBRA1) (N-Term) antibody (ABIN1105244) Activating molecule in BECN1-regulated autophagy protein 1 (Ambra1) antibody
Background publications Pagliarini, Wirawan, Romagnoli et al.: "Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response." in: Cell death and differentiation, Vol. 19, Issue 9, pp. 1495-504, 2012 (PubMed).

Armstrong, Corazzari, Martin et al.: "Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 8, pp. 2216-26, 2011 (PubMed).

Di Bartolomeo, Corazzari, Nazio et al.: "The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy." in: The Journal of cell biology, Vol. 191, Issue 1, pp. 155-68, 2010 (PubMed).

Catalog No. ABIN1105244
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