AMBRA1 antibody (Autophagy/beclin-1 Regulator 1) (N-Term)

Details for Product anti-AMBRA1 Antibody No. ABIN1105244, Supplier: Log in to see
Antigen
  • 2310079H06Rik
  • A130023A14
  • AA474864
  • AV021921
  • D030051N19Rik
  • mKIAA1736
  • Nyw1
  • DCAF3
  • WDR94
  • autophagy/beclin-1 regulator 1
  • activating molecule in beclin-1-regulated autophagy
  • autophagy/beclin 1 regulator 1
  • AMBRA1
  • LOC100219120
  • ambra1
  • Ambra1
Epitope
N-Term
33
18
18
15
5
3
2
1
Reactivity
Mouse (Murine)
110
74
68
4
4
Host
Rabbit
111
Clonality
Polyclonal
Conjugate
This AMBRA1 antibody is un-conjugated
3
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunohistochemistry (Frozen Sections) (IHC (fro)), Western Blotting (WB)
90
49
40
38
34
33
14
5
3
Options
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Immunogen Synthetic peptide derived from N-term domain of the mouse Ambra 1 protein.
Specificity This antibody reacts with Mouse 120 kDa Ambra1 protein.
Cross-Reactivity (Details) Species reactivity (expected):Human and Rat.
Species reactivity (tested):Mouse.
Purification Serum
Alternative Name AMBRA1 (AMBRA1 Antibody Abstract)
Background Synonyms: Activating molecule in BECN1-regulated autophagy protein 1, KIAA1736
Gene ID 228361
NCBI Accession NP_060219
Research Area Cancer, Autophagy, Neurogenesis
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Reconstitution Restore in distilled water.
Handling Advice Avoid repeated freezing and thawing.
Storage 4 °C/-20 °C
Storage Comment Prior to reconstitution store at -20 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
Supplier Images
Immunohistochemistry (Frozen Sections) (IHC (fro)) image for anti-AMBRA1 antibody (Autophagy/beclin-1 Regulator 1) (N-Term) (ABIN1105244) Activating molecule in BECN1-regulated autophagy protein 1 (Ambra1) antibody
Immunofluorescence (IF) image for anti-AMBRA1 antibody (Autophagy/beclin-1 Regulator 1) (N-Term) (ABIN1105244) Activating molecule in BECN1-regulated autophagy protein 1 (Ambra1) antibody
Background publications Pagliarini, Wirawan, Romagnoli, Ciccosanti, Lisi, Lippens, Cecconi, Fimia, Vandenabeele, Corazzari, Piacentini: "Proteolysis of Ambra1 during apoptosis has a role in the inhibition of the autophagic pro-survival response." in: Cell death and differentiation, Vol. 19, Issue 9, pp. 1495-504, 2012 (PubMed).

Armstrong, Corazzari, Martin, Pagliarini, Falasca, Hill, Ellis, Al Sabah, Redfern, Fimia, Piacentini, Lovat: "Oncogenic B-RAF signaling in melanoma impairs the therapeutic advantage of autophagy inhibition." in: Clinical cancer research : an official journal of the American Association for Cancer Research, Vol. 17, Issue 8, pp. 2216-26, 2011 (PubMed).

Di Bartolomeo, Corazzari, Nazio, Oliverio, Lisi, Antonioli, Pagliarini, Matteoni, Fuoco, Giunta, DAmelio, Nardacci, Romagnoli, Piacentini, Cecconi, Fimia: "The dynamic interaction of AMBRA1 with the dynein motor complex regulates mammalian autophagy." in: The Journal of cell biology, Vol. 191, Issue 1, pp. 155-68, 2010 (PubMed).