AGGF1 antibody

Catalog No. ABIN1105264

Product Details anti-AGGF1 Antibody

Target: AGGF1 (Angiogenic Factor with G Patch and FHA Domains 1 (AGGF1))

Reactivity: Human

Host: Rabbit

Clonality: Polyclonal

Conjugate: This AGGF1 antibody is un-conjugated

Application: Western Blotting (WB), Immunoprecipitation (IP), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Specificity: The antibody reacts with human VG5Q, a 84 kDa protein.

Cross-Reactivity (Details): Species reactivity (tested):Human

Purification: Protein A

Immunogen: VG5Q functions as an angiogenic factor in promoting angiogenesis and suppression of VG5Q expression inhibits vessel formation. Angiogenic factors are critical to the initiation of angiogenesis and maintenance of the vascular network. Angiogenesis has an essential role in pathological conditions such as cancer and various ischaemic and inflammatory diseases. VG5Q can bind to endothelial cells and promote cell proliferation, suggesting that the protein may act in an autocrine fashion. VG5Q interacts with TWEAK (also known as TNFSF12), another secreted angiogenic factor. VG5Q shows strong expression in blood vessels and is secreted when vessel formation is initiated. VG5Q protein was detected mostly in the cytoplasm and around the nuclei of human microvascular endothelial cells (HMVECs). Furthermore VG5Q is detected in human umbilical vein endothelial cells (HUVECs), human heart fibroblast (HHF) and ovarian cancer cells (OV-3), but low expression was detected in kidney cancer cells (RP-45), HeLa Cells and bladder cancer cells.

Isotype: IgG

Application Details

Application Notes: Optimal working dilution should be determined by the investigator.

Restrictions: For Research Use only

Handling

Concentration: 0.1 mg/mL

Buffer: PBS, 0.02 % sodium azide, 0.1 % bovine serum albumin

Preservative: Sodium azide

Precaution of Use: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Storage: 4 °C

Storage Comment: Store at 2 - 8 °C.

Target Details for AGGF1

Target: AGGF1 (Angiogenic Factor with G Patch and FHA Domains 1 (AGGF1))

Alternative Name: AGGF1 / VG5Q (AGGF1 Products)

Synonyms: RGD1310888 antibody, AGGF1 antibody, LOC100037685 antibody, im:7146636 antibody, zgc:152959 antibody, DKFZp459G1317 antibody, GPATC7 antibody, GPATCH7 antibody, HSU84971 antibody, HUS84971 antibody, VG5Q antibody, 2010009L17Rik antibody, 2310029P06Rik antibody, AW112072 antibody, Peg3 antibody, angiogenic factor with G patch and FHA domains 1 antibody, angiogenic factor with G-patch and FHA domains 1 antibody, Aggf1 antibody, AGGF1 antibody, aggf1 antibody, CC1G_06398 antibody

Background: Synonyms: Angiogenic factor VG5Q, Angiogenic factor with G patch and FHA domains 1, G patch domain-containing protein 7, GPATC7, GPATCH7, Vasculogenesis gene on 5q protein

Gene ID: 55109

NCBI Accession: NP_060516

UniProt: Q8N302