D10 has been characterized in the ISOBM TD-2 workshop and assigned by K. Nustad to group D of a cluster of 6 major epitopes of human alpha fetoprotein.
No Cross-Reactivity
Mouse (Murine), Rat (Rattus), Dog (Canine), Cow (Bovine)
Cross-Reactivity (Details)
Species reactivity (tested):Human.
Purification
Purified
Immunogen
A BALB/c mouse has been immunized with alpha fetoprotein isolated from serum of hepatoma patients. Splenocytes were fused with mouse myeloma cell line P3-X63-Ag8.653.
Human alpha fetoprotein is an oncofetal protein of 70 kD. Its gene has been cloned and sequenced and its structure identified. AFP is expressed in fetal liver and is normally absent in healthy adult tissues. It is expressed in all yolk sac tumors, in some germ cell tumors and in hepatocellular carcinomas.Synonyms: Alpha-1-fetoprotein, Alpha-fetoglobulin, HPAFP