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beta Amyloid antibody (Amyloid beta) (AA 1-16)

Details for Product anti-Abeta Antibody No. ABIN1105360, Supplier: Log in to see
Antigen
  • aaa
  • abeta
  • abpp
  • ad1
  • appi
  • ctfgamma
  • cvap
  • pn2
  • APP
  • ABPP
  • amyloid beta (A4) precursor protein
  • app
  • APP
Epitope
AA 1-16, N-Term
75
43
30
13
11
5
5
4
3
3
3
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reactivity
Human, Mouse (Murine)
243
53
39
19
11
9
8
6
6
5
4
4
3
3
3
3
2
1
1
1
Host
Mouse
191
79
5
1
Clonality (Clone)
Monoclonal ()
Conjugate
This beta Amyloid antibody is un-conjugated
15
7
5
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
1
1
1
1
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
186
148
81
75
68
67
32
24
11
5
5
2
2
2
2
2
2
1
1
1
1
1
Options
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Immunogen Synthetic amyloid beta peptide corresponding to amino acids 1-16 of human amyloid beta
Clone 2C8
Isotype IgG2b
Cross-Reactivity (Details) Species reactivity (tested):Human, weakly with mouse brain
Purification Protein-A Sepharose
Alternative Name Amyloid beta (Abeta Antibody Abstract)
Background Alzheimer's disease (AD) is the most common form of dementia in the elderly. The neuropathological hallmarks are neurofibrillary tangles and senile plaques. The major protein component of the plaques is a 39-42 amino acid peptide (ß-amyloid/Aß). Aß occurs in two predominant forms with different COOH-termini, Aß 40 and Aß 42, and overproduction of Aß 42 has been suggested to be the cause of familial early-onset AD. Aß generation depends on proteolytic cleavage of the amyloid precursor protein (APP) by two unknown proteases: ß-secretase and gamma-secretase. Recent study suggested that a transmembrane aspartic protease, termed beta-site APP-cleaving enzyme (BACE), functionally acts as the ß-secretase. This antibody recognizes N-terminal of Aß 40 and Aß 42 specifically.Synonyms: Amyloid beta peptide
Research Area Neurology, Alzheimer's Disease
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Concentration 1.0 mg/mL
Buffer PBS containing 50 % glycerol, pH 7.2, without preservatives
Preservative Without preservative
Handling Advice Avoid repeated freezing and thawing.
Storage -20 °C
Storage Comment Store (in aliquots) at -20 °C.
Supplier Images
Immunohistochemistry (IHC) image for anti-beta Amyloid antibody (Amyloid beta) (AA 1-16) (ABIN1105360) anti-Amyloid beta (Abeta) (AA 1-16), (N-Term) antibody
Western Blotting (WB) image for anti-beta Amyloid antibody (Amyloid beta) (AA 1-16) (ABIN1105360) anti-Amyloid beta (Abeta) (AA 1-16), (N-Term) antibody (Image 2)
Background publications Wang, Malmberg, Ek, Larsson, Palmberg: "Swine dust induces cytokine secretion from human epithelial cells and alveolar macrophages." in: Clinical and experimental immunology, Vol. 115, Issue 1, pp. 6-12, 1999 (PubMed).

Vassar, Bennett, Babu-Khan, Kahn, Mendiaz, Denis, Teplow, Ross, Amarante, Loeloff, Luo, Fisher, Fuller, Edenson, Lile, Jarosinski, Biere, Curran, Burgess, Louis, Collins, Treanor, Rogers, Citron: "Beta-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE." in: Science (New York, N.Y.), Vol. 286, Issue 5440, pp. 735-41, 1999 (PubMed).

Saito, Pietromonaco, Loo, Farquhar: "Complete cloning and sequencing of rat gp330/\megalin,\' a distinctive member of the low density lipoprotein receptor gene family.'" in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 91, Issue 21, pp. 9725-9, 1994 (PubMed).