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APOE antibody

APOE Reactivity: Human IHC (p), IHC (fro), EIA Host: Mouse Monoclonal 3D12 unconjugated
Catalog No. ABIN1105420
  • Target See all APOE Antibodies
    APOE (Apolipoprotein E (APOE))
    Reactivity
    • 102
    • 75
    • 56
    • 2
    • 2
    • 2
    • 1
    • 1
    Human
    Host
    • 103
    • 22
    • 13
    • 2
    Mouse
    Clonality
    • 105
    • 34
    Monoclonal
    Conjugate
    • 60
    • 18
    • 12
    • 7
    • 4
    • 4
    • 4
    • 4
    • 4
    • 4
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    • 2
    This APOE antibody is un-conjugated
    Application
    • 111
    • 57
    • 39
    • 39
    • 30
    • 25
    • 20
    • 12
    • 10
    • 9
    • 7
    • 5
    • 3
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Enzyme Immunoassay (EIA)
    Specificity
    The antibody reacts with Very Low Density Lipoproteins (VLDL) of Human plasma. It is specific for Human Apo-E. No crossreactions with other Human plasma proteins were detected. This antibody reacts as well with LDL as with VLDL. This antibody recognizes all alleles of Apo-E. In combination with other mabs for detection of VLDL in plasma, and for the specific detection of Apo-E. The antibody is also useful for detection of Apo-E in tissue sections.
    Cross-Reactivity (Details)
    Species reactivity (tested):Human.
    Purification
    Ammonium sulfate precipitation + DEAE-cellulose chromatography, gradient elution
    Clone
    3D12
    Isotype
    IgG1
    Top Product
    Discover our top product APOE Primary Antibody
  • Application Notes
    Optimal working dilution should be determined by the investigator.
    Restrictions
    For Research Use only
  • Format
    Liquid
    Reconstitution
    Restore with 1 mL sterile water and add preservative if preferred.
    Concentration
    0.5 mg/mL (prior to lyophilization)
    Buffer
    PBS, None
    Handling Advice
    Avoid repeated freezing and thawing.
    Storage
    4 °C/-20 °C
    Storage Comment
    Prior to reconstitution store at 2-8 °C. Following reconstitution store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.
  • Target
    APOE (Apolipoprotein E (APOE))
    Alternative Name
    Apolipoprotein E (Apo E) (APOE Products)
    Synonyms
    ad2 antibody, apoprotein antibody, im:7036787 antibody, wu:fb69a05 antibody, zgc:110064 antibody, apoe antibody, AI255918 antibody, AD2 antibody, LDLCQ5 antibody, LPG antibody, APOEA antibody, Apo-E antibody, apolipoprotein E antibody, apolipoprotein Ea antibody, apoe antibody, apoea antibody, Apoe antibody, APOE antibody
    Background
    Apolipoprotein E is essential for the normal catabolism of triglyceride rich lipoprotein constituents. The apolipoprotein E gene is mapped to chromosome 19 in a cluster with APOC1 and APOC2. Defects in Apolipoprotein E result in familial dysbetalipoproteinemia, or type III hyperlipoproteinemia (HLP III), in which increased plasma cholesterol and triglycerides are the consequence of impaired clearance of chylomicron and VLDL remnants. Mutations in the APOE gene confer susceptibility to Alzheimer's disease by affecting amyloid-beta deposition.Synonyms: Apo-E, ApoE
    Gene ID
    348
    NCBI Accession
    NP_000032
    UniProt
    P02649
    Pathways
    Regulation of Cell Size, Lipid Metabolism
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