Ataxin 1 antibody (ATXN1)

Details for Product anti-ATXN1 Antibody No. ABIN1105458, Supplier: Log in to see
Antigen
  • ATXN1
  • SCA1
  • ataxin 1b
  • atxn1
  • CG4547
  • Dmel\\CG4547
  • dAtx-1
  • dAtx1
  • ATX1
  • D6S504E
  • 2900016G23Rik
  • Atx1
  • C85907
  • ENSMUSG00000074917
  • Gm10786
  • Sca1
  • sca1
  • ataxin 1
  • ataxin 1b
  • Ataxin 1
  • ataxin 1-like
  • ATXN1
  • atxn1b
  • Atx-1
  • Atxn1
  • ATXN1L
Alternatives
anti-Human Ataxin 1 antibody for ELISA
Reactivity
Human
195
145
119
6
4
4
3
2
2
2
1
1
1
1
Host
Mouse
106
90
9
3
Clonality (Clone)
Monoclonal ()
Conjugate
This Ataxin 1 antibody is un-conjugated
10
9
7
6
6
6
4
4
4
4
4
4
4
4
4
4
2
2
2
2
2
2
2
2
2
2
2
2
2
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
157
74
65
65
55
41
26
12
11
9
2
2
2
Options
Supplier
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Clone 2F5
Isotype IgG1
Specificity Recognizes Ataxin-1
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name Ataxin-1 (ATXN1 Antibody Abstract)
Background Defects in ATXN1 are the cause of spinocerebellar ataxia type 1 (SCA1) [MIM:164400], also known as olivopontocerebellar atrophy I (OPCA I or OPCA1). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to cerebellum degeneration with variable involvement of the brainstem and spinal cord. SCA1 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA1 is caused by expansion of a CAG repeat in the coding region of ATXN1. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.Synonyms: ATX1, ATXN1, Ataxin 1, SCA1, Spinocerebellar ataxia type 1 protein
Molecular Weight 87 kDa
Gene ID 6310
Pathways Synaptic Membrane
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Immunofluorescence (IF) image for anti-Ataxin 1 antibody (ATXN1) (ABIN1105458) anti-Ataxin 1 (ATXN1) antibody
Immunohistochemistry (IHC) image for anti-Ataxin 1 antibody (ATXN1) (ABIN1105458) anti-Ataxin 1 (ATXN1) antibody (Image 2)
Western Blotting (WB) image for anti-Ataxin 1 antibody (ATXN1) (ABIN1105458) anti-Ataxin 1 (ATXN1) antibody (Image 3)
Flow Cytometry (FACS) image for anti-Ataxin 1 antibody (ATXN1) (ABIN1105458) anti-Ataxin 1 (ATXN1) antibody (Image 4)
Background publications Lim, Crespo-Barreto, Jafar-Nejad, Bowman, Richman, Hill, Orr, Zoghbi: "Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1." in: Nature, Vol. 452, Issue 7188, pp. 713-8, 2008 (PubMed).

Li, Wu, Guo, Wang, Wang: "Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis." in: Biochemical and biophysical research communications, Vol. 371, Issue 1, pp. 159-62, 2008 (PubMed).

Hong, Lee, Cho, Kang: "UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1." in: Biochemical and biophysical research communications, Vol. 371, Issue 2, pp. 256-60, 2008 (PubMed).

Krishna, Mohan, Yashavantha, Rammurthy, Kiran Kumar, Mittal, Tyagi, Mukerji, Jain, Pal, Purushottam: "SCA 1, SCA 2 & SCA 3/MJD mutations in ataxia syndromes in southern India." in: The Indian journal of medical research, Vol. 126, Issue 5, pp. 465-70, 2007 (PubMed).