Ataxin 1 (ATXN1) antibody

Details for Product No. ABIN1105458
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Antigen
Synonyms ATXN1, SCA1, ataxin 1b, atxn1, CG4547, Dmel\\CG4547, dAtx-1, dAtx1, ATX1, D6S504E, 2900016G23Rik, Atx1, C85907, ENSMUSG00000074917, Gm10786, Sca1, sca1
Reactivity
Human
(167), (101), (75), (27), (26), (26), (12), (2), (1), (1), (1)
Host
Mouse
(83), (83), (6), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(9), (8), (6), (6), (5), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2)
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(126), (57), (51), (41), (37), (31), (30), (15), (8), (2), (2), (1), (1), (1), (1)
Pubmed 4 references available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN1105458
390.50 $
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Clone 2F5
Isotype IgG1
Specificity Recognizes Ataxin-1
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name Ataxin-1
Background Defects in ATXN1 are the cause of spinocerebellar ataxia type 1 (SCA1) [MIM:164400], also known as olivopontocerebellar atrophy I (OPCA I or OPCA1). Spinocerebellar ataxia is a clinically and genetically heterogeneous group of cerebellar disorders. Patients show progressive incoordination of gait and often poor coordination of hands, speech and eye movements, due to cerebellum degeneration with variable involvement of the brainstem and spinal cord. SCA1 belongs to the autosomal dominant cerebellar ataxias type I (ADCA I) which are characterized by cerebellar ataxia in combination with additional clinical features like optic atrophy, ophthalmoplegia, bulbar and extrapyramidal signs, peripheral neuropathy and dementia. SCA1 is caused by expansion of a CAG repeat in the coding region of ATXN1. Longer expansions result in earlier onset and more severe clinical manifestations of the disease.Synonyms: ATX1, ATXN1, Ataxin 1, SCA1, Spinocerebellar ataxia type 1 protein
Molecular Weight 87 kDa
Gene ID 6310
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
anti-Ataxin 1 (ATXN1) antibody anti-Ataxin 1 (ATXN1) antibody
anti-Ataxin 1 (ATXN1) antibody (2) anti-Ataxin 1 (ATXN1) antibody (Image 2)
anti-Ataxin 1 (ATXN1) antibody (3) anti-Ataxin 1 (ATXN1) antibody (Image 3)
anti-Ataxin 1 (ATXN1) antibody (4) anti-Ataxin 1 (ATXN1) antibody (Image 4)
Background publications Krishna, Mohan, Yashavantha et al.: "SCA 1, SCA 2 & SCA 3/MJD mutations in ataxia syndromes in southern India." in: The Indian journal of medical research, Vol. 126, Issue 5, pp. 465-70, 2007 (PubMed).

Lim, Crespo-Barreto, Jafar-Nejad et al.: "Opposing effects of polyglutamine expansion on native protein complexes contribute to SCA1." in: Nature, Vol. 452, Issue 7188, pp. 713-8, 2008 (PubMed).

Li, Wu, Guo et al.: "Sphingosine 1-phosphate induces Mcl-1 upregulation and protects multiple myeloma cells against apoptosis." in: Biochemical and biophysical research communications, Vol. 371, Issue 1, pp. 159-62, 2008 (PubMed).

Hong, Lee, Cho et al.: "UbcH6 interacts with and ubiquitinates the SCA1 gene product ataxin-1." in: Biochemical and biophysical research communications, Vol. 371, Issue 2, pp. 256-60, 2008 (PubMed).

Validation Images
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