B-Cell CLL/lymphoma 10 (BCL10) antibody

Details for Product No. ABIN1105500
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Antigen
Synonyms BCL10, AI132454, BCL-10, C81403, CARMEN, CIPER, CLAP, ME10, cE10, c-E10, mE10
Reactivity
Human, Mouse (Murine)
(182), (59), (48), (12), (12), (12), (1)
Host
Mouse
(119), (61), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(5), (4), (4), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Frozen Paraffin-embedded Sections) (IHC (frpe)), Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))
(126), (65), (46), (41), (34), (23), (22), (20), (13), (9), (4), (1), (1), (1)
Pubmed 3 references available
Quantity 0.1 mg
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1105500
335.50 $
Plus shipping costs $45.00

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  • +1 404 474 4654
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Clone 4F8
Isotype IgG1
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Purified
Alternative Name Bcl-10
Background Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.Synonyms: B-cell CLL/lymphoma 10, BCL10, CARD-containing molecule enhancing NF-kappa-B, CARD-like apoptotic protein, CED-3/ICH-1 prodomain homologous E10-like regulator, CIPER, CLAP, Cellular homolog of vCARMEN, Cellular-E10, Mammalian CARD-containing adapter molecule E10, c-E10, cCARMEN, hCLAP, mE10
Gene ID 8915
Research Area Cancer
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS, 0.03 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
anti-B-Cell CLL/lymphoma 10 (BCL10) antibody anti-B-Cell CLL/lymphoma 10 (BCL10) antibody
anti-B-Cell CLL/lymphoma 10 (BCL10) antibody (2) anti-B-Cell CLL/lymphoma 10 (BCL10) antibody (Image 2)
anti-B-Cell CLL/lymphoma 10 (BCL10) antibody (3) anti-B-Cell CLL/lymphoma 10 (BCL10) antibody (Image 3)
anti-B-Cell CLL/lymphoma 10 (BCL10) antibody (4) anti-B-Cell CLL/lymphoma 10 (BCL10) antibody (Image 4)
Background publications Rudd: "Adaptors and molecular scaffolds in immune cell signaling." in: Cell, Vol. 96, Issue 1, pp. 5-8, 1999 (PubMed).

Wang, Guo, Huang et al.: "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B." in: The Journal of biological chemistry, Vol. 276, Issue 24, pp. 21405-9, 2001 (PubMed).

Lucas, Yonezumi, Inohara et al.: "Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway." in: The Journal of biological chemistry, Vol. 276, Issue 22, pp. 19012-9, 2001 (PubMed).

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