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BCL10 antibody (B-Cell CLL/lymphoma 10)

Details for Product anti-BCL10 Antibody No. ABIN1105500, Supplier: Log in to see
Antigen
  • BCL10
  • AI132454
  • BCL-10
  • C81403
  • CARMEN
  • CIPER
  • CLAP
  • ME10
  • cE10
  • c-E10
  • mE10
Alternatives
anti-Human BCL10 antibody for Western Blotting
Reactivity
Human, Mouse (Murine)
212
49
38
1
1
Host
Mouse
118
93
3
Clonality (Clone)
Monoclonal ()
Conjugate
This BCL10 antibody is un-conjugated
8
6
6
6
2
2
2
2
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
158
71
70
54
42
35
16
16
12
3
1
1
1
Supplier
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Clone 4F8
Isotype IgG1
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Purified
Alternative Name Bcl-10 (BCL10 Antibody Abstract)
Background Bcl-10 (B-cell CLL/lymphoma 10), also known as CLAP, Me10, CIPER, c-E10, CARMEN. Entrez Protein NP_003912. It is a protein containing a caspase recruitment domain (CARD). It plays an important role in apoptosis and activating NF-kappaB. The research suggested that it interacted with other CARD domain containing proteins including CARD9, 10, 11 and 14, which were thought to function as upstream regulators in NF-kappaB signaling. Bcl-10 is found to form a complex with MALT1 which encoded by another gene known to be translocated in MALT lymphoma. MALT1 and Bcl-10 are thought to synergize in the activation of NF-kappaB, and the deregulation of either of them may contribute to the same pathogenetic process that leads to the malignancy.Synonyms: B-cell CLL/lymphoma 10, BCL10, CARD-containing molecule enhancing NF-kappa-B, CARD-like apoptotic protein, CED-3/ICH-1 prodomain homologous E10-like regulator, CIPER, CLAP, Cellular homolog of vCARMEN, Cellular-E10, Mammalian CARD-containing adapter molecule E10, c-E10, cCARMEN, hCLAP, mE10
Gene ID 8915
Research Area Cancer
Pathways TCR Signaling, Fc-epsilon Receptor Signaling Pathway
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Buffer PBS, 0.03 % Sodium Azide
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Supplier Images
Flow Cytometry (FACS) image for anti-BCL10 antibody (B-Cell CLL/lymphoma 10) (ABIN1105500) anti-B-Cell CLL/lymphoma 10 (BCL10) antibody
Western Blotting (WB) image for anti-BCL10 antibody (B-Cell CLL/lymphoma 10) (ABIN1105500) anti-B-Cell CLL/lymphoma 10 (BCL10) antibody (Image 2)
Immunohistochemistry (IHC) image for anti-BCL10 antibody (B-Cell CLL/lymphoma 10) (ABIN1105500) anti-B-Cell CLL/lymphoma 10 (BCL10) antibody (Image 3)
Immunofluorescence (IF) image for anti-BCL10 antibody (B-Cell CLL/lymphoma 10) (ABIN1105500) anti-B-Cell CLL/lymphoma 10 (BCL10) antibody (Image 4)
Background publications Lucas, Yonezumi, Inohara et al.: "Bcl10 and MALT1, independent targets of chromosomal translocation in malt lymphoma, cooperate in a novel NF-kappa B signaling pathway." in: The Journal of biological chemistry, Vol. 276, Issue 22, pp. 19012-9, 2001 (PubMed).

Wang, Guo, Huang et al.: "Card10 is a novel caspase recruitment domain/membrane-associated guanylate kinase family member that interacts with BCL10 and activates NF-kappa B." in: The Journal of biological chemistry, Vol. 276, Issue 24, pp. 21405-9, 2001 (PubMed).

Rudd: "Adaptors and molecular scaffolds in immune cell signaling." in: Cell, Vol. 96, Issue 1, pp. 5-8, 1999 (PubMed).