B-Cell CLL/lymphoma 2 (BCL2) antibody

Details for Product No. ABIN1105507
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Antigen
Synonyms AW986256, Bcl-2, C430015F12Rik, D630044D05Rik, D830018M01Rik, PPP1R50, BCL-2, bcl-2, Bcl2
Reactivity
Human
(454), (160), (126), (54), (36), (36), (14), (12), (3), (2), (2)
Host
Rabbit
(372), (126), (9), (7), (1)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(22), (17), (14), (12), (9), (7), (7), (7), (7), (7), (7), (7), (7), (6), (1), (1), (1)
Application
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))
(340), (181), (141), (122), (90), (87), (70), (58), (56), (42), (24), (10), (5), (2), (2), (2), (2), (1), (1)
Pubmed 6 references available
Quantity 1 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
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Catalog No. ABIN1105507
1,028.50 $
Plus shipping costs $45.00

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Clone E17
Isotype IgG
Specificity This antibody reacts to BCL-2.
Purification Supernatant
Alternative Name Bcl-2
Background Anti-bcl-2 has shown consistent negative reaction on reactive germinal centers and positive staining of neoplastic follicles in follicular lymphoma. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. This antibody may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative. Anti-bcl-2 has been used as a predictive biomarker for recurrence in the case of radical prostatectomy for prostate cancer, and has shown promise as a prognostic marker in the case of cancer of the breast and nonsmall cell carcinoma of the lung.
Alternate names: Apoptosis regulator Bcl-2, B-Cell CLL/lymphoma 2, BCL2, Bcl-2 alpha
Gene ID 596
NCBI Accession NP_000624
UniProt P10415
Research Area Cancer, Apoptosis/Necrosis
Restrictions For Research Use only
Format Liquid
Buffer PBS, pH 7.4 0,09% sodium azide 0,9% BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store the antibody undiluted at 2-8°C.
Expiry Date 12 months
Background publications Pezzella, Tse, Cordell et al.: "Expression of the bcl-2 oncogene protein is not specific for the 14;18 chromosomal translocation." in: The American journal of pathology, Vol. 137, Issue 2, pp. 225-32, 1990 (PubMed).

Hockenbery, Nuñez, Milliman et al.: "Bcl-2 is an inner mitochondrial membrane protein that blocks programmed cell death." in: Nature, Vol. 348, Issue 6299, pp. 334-6, 1991 (PubMed).

Cleary, Smith, Sklar: "Cloning and structural analysis of cDNAs for bcl-2 and a hybrid bcl-2/immunoglobulin transcript resulting from the t(14;18) translocation." in: Cell, Vol. 47, Issue 1, pp. 19-28, 1986 (PubMed).

Tsujimoto, Croce: "Analysis of the structure, transcripts, and protein products of bcl-2, the gene involved in human follicular lymphoma." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 83, Issue 14, pp. 5214-8, 1986 (PubMed).

Moul: "Angiogenesis, p53, bcl-2 and Ki-67 in the progression of prostate cancer after radical prostatectomy." in: European urology, Vol. 35, Issue 5-6, pp. 399-407, 1999 (PubMed).

Ciocca, Elledge: "Molecular markers for predicting response to tamoxifen in breast cancer patients." in: Endocrine, Vol. 13, Issue 1, pp. 1-10, 2001 (PubMed).

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