BCL2 antibody (B-Cell CLL/lymphoma 2) (PE)

Details for Product anti-BCL2 Antibody No. ABIN1105508, Supplier: Log in to see
Antigen
  • Bcl-2
  • PPP1R50
  • bcl-2
  • AW986256
  • C430015F12Rik
  • D630044D05Rik
  • D830018M01Rik
  • BCL-2
  • Bcl2
  • B-cell CLL/lymphoma 2
  • B cell leukemia/lymphoma 2
  • B-cell leukemia/lymphoma 2
  • B-cell leukemia/lymphoma 2-like
  • B-cell CLL/lymphoma 2 protein
  • BCL2
  • Bcl2
  • LOC100224888
  • bcl2
  • LOC100359045
  • BCL-2
Alternatives
anti-Rat (Rattus) BCL2 antibody for Immunofluorescence (fixed cells)
Reactivity
Human, Mouse (Murine), Rat (Rattus)
1001
252
210
54
28
22
18
18
5
4
4
3
2
2
2
2
Host
Mouse
549
517
19
6
2
2
2
Clonality (Clone)
Monoclonal ()
Conjugate
This BCL2 antibody is conjugated to PE
49
48
42
37
24
23
22
15
15
13
13
13
13
13
13
13
12
12
12
7
7
7
6
6
6
6
6
6
6
2
2
1
1
1
1
1
1
1
1
1
1
1
Application
Flow Cytometry (FACS)
791
374
361
309
307
297
228
191
170
81
40
15
14
13
12
11
9
4
3
2
1
1
1
1
1
1
1
Options
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Immunogen Recombinant rat Bcl-2beta
Clone 83-8B
Isotype IgG1
Specificity This antibody reacts with Bcl-2.
Cross-Reactivity (Details) Species reactivity (tested):Human, mouse, rat
Purification Protein A agarose
Alternative Name Bcl-2 (BCL2 Antibody Abstract)
Background The Bcl-2 related genes can inhibit (Bcl-XL and Mcl-1) or induce (Bax, Bcl-Xs, Bag and Bad) apoptosis in several systems. Bad was identified as a Bcl-2 interacting protein using a yeast two hybrid screening and λ expression cloning. It has homology to Bcl-2 within the Bcl-2 homolog domains 1 and 2 (BH1 and BH2). In mammalian cells, Bad selectively heterodimerizes with Bcl-XL as well as Bcl-2, but not with other Bcl-2 family members (Bax, Bcl-Xs, Mcl-1 and A1). When Bad heterodimerized with Bcl-XL, it displaced Bax from Bcl-XL and promoted cell death.Synonyms: Apoptosis regulator Bcl-2, B-Cell CLL/lymphoma 2, BCL2, Bcl-2 alpha
Gene ID 24224
NCBI Accession NP_058689
UniProt P49950
Research Area Cancer, Apoptosis/Necrosis
Pathways MAPK Signaling, PI3K-Akt Signaling, Apoptosis, Caspase Cascade in Apoptosis, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Skeletal Muscle Fiber Development, Autophagy, Smooth Muscle Cell Migration, Negative Regulation of intrinsic apoptotic Signaling
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Buffer PBS, 0.09 % NaN3, 1 % BSA
Preservative Sodium azide
Precaution of Use This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Storage 4 °C
Storage Comment Store at 2 - 8 °C.
Supplier Images
Flow Cytometry (FACS) image for anti-BCL2 antibody (B-Cell CLL/lymphoma 2)  (PE) (ABIN1105508) anti-B-Cell CLL/lymphoma 2 (BCL2) antibody (PE)
Background publications Gallatin, Weissman, Butcher: "A cell-surface molecule involved in organ-specific homing of lymphocytes. 1983." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 177, Issue 1, pp. 5-9, 2006 (PubMed).

Tanaka, Yoshimi, Maeyama, Hagimoto, Kuwano, Hara: "Resistance to Fas-mediated apoptosis in human lung fibroblast." in: The European respiratory journal, Vol. 20, Issue 2, pp. 359-68, 2002 (PubMed).