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BLK antibody (B Lymphoid Tyrosine Kinase)

Details for Product anti-BLK Antibody No. ABIN1105539, Supplier: Log in to see
Antigen
  • bltk
  • si:dkey-33i22.2
  • zgc:136231
  • MODY11
  • B lymphoid tyrosine kinase
  • B lymphoid kinase
  • blk
  • BLK
  • Blk
Alternatives
anti-Human BLK antibody for ELISA
Reactivity
Human
172
62
40
3
2
1
1
1
1
Host
Mouse
89
74
14
Clonality (Clone)
Monoclonal ()
Conjugate
This BLK antibody is un-conjugated
5
5
5
4
3
3
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
139
97
77
18
13
8
6
5
5
4
3
2
Options
Supplier
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Clone 1-00E-006
Isotype IgG1
Specificity Recognizes BLK
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name BLK (BLK Antibody Abstract)
Background Blk is a Src family protein tyrosine kinase expressed in all stages of B cell development . Activation of B cells by various ligands is accompanied by activation of Blk . It has been suggested that Blk is involved in the control of B cell differentiation and proliferation . Blk transcripts have also been detected in human thymocytes, but not in mature T cells, implicating that Blk may play an important role in thymopoiesis . Blk function may be redundant, however, as mice that do not express Blk are not impaired with respect to B cell development and immune response .Synonyms: B lymphocyte kinase, Tyrosine-protein kinase BLK, p55-BLK, p55BLK
Molecular Weight 58 kDa
Gene ID 640
Research Area Apoptosis/Necrosis
Pathways Positive Regulation of Peptide Hormone Secretion
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Flow Cytometry (FACS) image for anti-BLK antibody (B Lymphoid Tyrosine Kinase) (ABIN1105539) anti-B Lymphoid Tyrosine Kinase (BLK) antibody
Western Blotting (WB) image for anti-BLK antibody (B Lymphoid Tyrosine Kinase) (ABIN1105539) anti-B Lymphoid Tyrosine Kinase (BLK) antibody (Image 2)
Immunofluorescence (IF) image for anti-BLK antibody (B Lymphoid Tyrosine Kinase) (ABIN1105539) anti-B Lymphoid Tyrosine Kinase (BLK) antibody (Image 3)
Background publications Yang, Ng, Zhao, Hirankarn, Lau, Mok, Chan, Wong, Lee, Mok, Wong, Avihingsanon, Lee, Ho, Lee, Wong, Lau: "Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese." in: Genes and immunity, Vol. 10, Issue 3, pp. 219-26, 2009 (PubMed).

Borowiec, Liew, Thompson, Boonyasrisawat, Hu, Mlynarski, El Khattabi, Kim, Marselli, Rich, Krolewski, Bonner-Weir, Sharma, Sale, Mychaleckyj, Kulkarni, Doria: "Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 34, pp. 14460-5, 2009 (PubMed).

Hom, Graham, Modrek, Taylor, Ortmann, Garnier, Lee, Chung, Ferreira, Pant, Ballinger, Kosoy, Demirci, Kamboh, Kao, Tian, Gunnarsson, Bengtsson, Rantapää-Dahlqvist, Petri, Manzi, Seldin, Rönnblom et al.: "Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. ..." in: The New England journal of medicine, Vol. 358, Issue 9, pp. 900-9, 2008 (PubMed).