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BLK antibody (B Lymphoid Tyrosine Kinase)

Details for Product anti-BLK Antibody No. ABIN1105539, Supplier: Log in to see
Antigen
  • bltk
  • si:dkey-33i22.2
  • zgc:136231
  • MODY11
Reactivity
Human
136
46
33
2
1
1
1
Host
Mouse
83
45
13
Clonality (Clone)
Monoclonal ()
Conjugate
This BLK antibody is un-conjugated
4
4
4
3
3
3
1
1
1
1
1
1
1
1
1
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
106
84
66
14
11
5
4
4
3
3
3
Supplier
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Clone 1-00E-006
Isotype IgG1
Specificity Recognizes BLK
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name BLK (BLK Antibody Abstract)
Background Blk is a Src family protein tyrosine kinase expressed in all stages of B cell development . Activation of B cells by various ligands is accompanied by activation of Blk . It has been suggested that Blk is involved in the control of B cell differentiation and proliferation . Blk transcripts have also been detected in human thymocytes, but not in mature T cells, implicating that Blk may play an important role in thymopoiesis . Blk function may be redundant, however, as mice that do not express Blk are not impaired with respect to B cell development and immune response .Synonyms: B lymphocyte kinase, Tyrosine-protein kinase BLK, p55-BLK, p55BLK
Molecular Weight 58 kDa
Gene ID 640
Research Area Apoptosis/Necrosis
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Flow Cytometry (FACS) image for anti-BLK antibody (B Lymphoid Tyrosine Kinase) (ABIN1105539) anti-B Lymphoid Tyrosine Kinase (BLK) antibody
Western Blotting (WB) image for anti-BLK antibody (B Lymphoid Tyrosine Kinase) (ABIN1105539) anti-B Lymphoid Tyrosine Kinase (BLK) antibody (Image 2)
Immunofluorescence (IF) image for anti-BLK antibody (B Lymphoid Tyrosine Kinase) (ABIN1105539) anti-B Lymphoid Tyrosine Kinase (BLK) antibody (Image 3)
Background publications Borowiec, Liew, Thompson et al.: "Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 34, pp. 14460-5, 2009 (PubMed).

Yang, Ng, Zhao et al.: "Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese." in: Genes and immunity, Vol. 10, Issue 3, pp. 219-26, 2009 (PubMed).

Hom, Graham, Modrek et al.: "Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. ..." in: The New England journal of medicine, Vol. 358, Issue 9, pp. 900-9, 2008 (PubMed).