B Lymphoid Tyrosine Kinase (BLK) antibody

Details for Product No. ABIN1105539
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Antigen
Synonyms bltk, si:dkey-33i22.2, zgc:136231, MODY11
Reactivity
Human
(109), (49), (33), (2), (1), (1)
Host
Mouse
(71), (44), (3)
Clonality (Clone)
Monoclonal ()
Conjugate
Un-conjugated
(2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Application
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
(85), (68), (57), (19), (10), (7), (6), (4), (4), (4), (4), (3), (3), (1)
Pubmed 3 references available
Quantity 0.1 mL
Shipping to United States (Change)
Availability Will be delivered in 6 to 8 Business Days
Request Want additional data for this product?

The Independent Validation Initiative strives to provide you with high quality data. Find out more

Catalog No. ABIN1105539
390.50 $
Plus shipping costs $45.00

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Clone 1-00E-006
Isotype IgG1
Specificity Recognizes BLK
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name BLK
Background Blk is a Src family protein tyrosine kinase expressed in all stages of B cell development . Activation of B cells by various ligands is accompanied by activation of Blk . It has been suggested that Blk is involved in the control of B cell differentiation and proliferation . Blk transcripts have also been detected in human thymocytes, but not in mature T cells, implicating that Blk may play an important role in thymopoiesis . Blk function may be redundant, however, as mice that do not express Blk are not impaired with respect to B cell development and immune response .Synonyms: B lymphocyte kinase, Tyrosine-protein kinase BLK, p55-BLK, p55BLK
Molecular Weight 58 kDa
Gene ID 640
Research Area Apoptosis/Necrosis
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
anti-B Lymphoid Tyrosine Kinase (BLK) antibody anti-B Lymphoid Tyrosine Kinase (BLK) antibody
anti-B Lymphoid Tyrosine Kinase (BLK) antibody (2) anti-B Lymphoid Tyrosine Kinase (BLK) antibody (Image 2)
anti-B Lymphoid Tyrosine Kinase (BLK) antibody (3) anti-B Lymphoid Tyrosine Kinase (BLK) antibody (Image 3)
Background publications Hom, Graham, Modrek et al.: "Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX." in: The New England journal of medicine, Vol. 358, Issue 9, pp. 900-9, 2008 (PubMed).

Yang, Ng, Zhao et al.: "Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese." in: Genes and immunity, Vol. 10, Issue 3, pp. 219-26, 2009 (PubMed).

Borowiec, Liew, Thompson et al.: "Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 34, pp. 14460-5, 2009 (PubMed).

Validation Images
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