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BLK antibody (B Lymphoid Tyrosine Kinase)

Details for Product anti-BLK Antibody No. ABIN1105539, Supplier: Login to see New
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Synonyms bltk, si:dkey-33i22.2, zgc:136231, MODY11
(141), (49), (33), (2), (1), (1), (1)
(88), (48), (13)
Clonality (Clone)
Monoclonal ()
This BLK antibody is un-conjugated
(4), (4), (4), (3), (3), (3), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Enzyme Immunoassay (EIA), Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
(113), (87), (69), (17), (11), (5), (4), (4), (4), (3), (3)
Pubmed 3 references available
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Quantity 0.1 mL
Shipping to United States ( )
Availability Will be delivered in 6 to 8 Business Days
Clone 1-00E-006
Isotype IgG1
Specificity Recognizes BLK
Cross-Reactivity (Details) Species reactivity (tested):Human.
Purification Ascites
Alternative Name BLK (BLK Antibody Abstract)
Background Blk is a Src family protein tyrosine kinase expressed in all stages of B cell development . Activation of B cells by various ligands is accompanied by activation of Blk . It has been suggested that Blk is involved in the control of B cell differentiation and proliferation . Blk transcripts have also been detected in human thymocytes, but not in mature T cells, implicating that Blk may play an important role in thymopoiesis . Blk function may be redundant, however, as mice that do not express Blk are not impaired with respect to B cell development and immune response .Synonyms: B lymphocyte kinase, Tyrosine-protein kinase BLK, p55-BLK, p55BLK
Molecular Weight 58 kDa
Gene ID 640
Research Area Apoptosis/Necrosis
Application Notes Optimal working dilution should be determined by the investigator.
Restrictions For Research Use only
Format Liquid
Supplier Images
Flow Cytometry (FACS) image for anti-BLK antibody (B Lymphoid Tyrosine Kinase) (ABIN1105539) anti-B Lymphoid Tyrosine Kinase (BLK) antibody
Western Blotting (WB) image for anti-BLK antibody (B Lymphoid Tyrosine Kinase) (ABIN1105539) anti-B Lymphoid Tyrosine Kinase (BLK) antibody (Image 2)
Immunofluorescence (IF) image for anti-BLK antibody (B Lymphoid Tyrosine Kinase) (ABIN1105539) anti-B Lymphoid Tyrosine Kinase (BLK) antibody (Image 3)
Background publications Borowiec, Liew, Thompson et al.: "Mutations at the BLK locus linked to maturity onset diabetes of the young and beta-cell dysfunction." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, Issue 34, pp. 14460-5, 2009 (PubMed).

Yang, Ng, Zhao et al.: "Population differences in SLE susceptibility genes: STAT4 and BLK, but not PXK, are associated with systemic lupus erythematosus in Hong Kong Chinese." in: Genes and immunity, Vol. 10, Issue 3, pp. 219-26, 2009 (PubMed).

Hom, Graham, Modrek et al.: "Association of systemic lupus erythematosus with C8orf13-BLK and ITGAM-ITGAX. ..." in: The New England journal of medicine, Vol. 358, Issue 9, pp. 900-9, 2008 (PubMed).

Catalog No. ABIN1105539
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